A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
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DOI：
10.1038/nm1309
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发表时间：
2005-11-01
期刊：
影响因子：
82.9
通讯作者：
Ferrara, JLM
中科院分区：
文献类型：
--
作者：
Reddy, P;Maeda, Y;Ferrara, JLM
异基因骨髓移植（BMT）后的移植物抗白血病（GVL）反应是针对恶性疾病的最有效免疫疗法形式之一（1）。抗原呈递细胞（APC）对于诱导移植物抗宿主病（GVHD）（同种异体BMT最严重的并发症）至关重要（2-6），但其在GVL应答中的作用尚不清楚。利用一系列临床相关的小鼠GVL肿瘤模型，我们发现肿瘤上的APC和同种异体抗原表达对GVL至关重要。此外，宿主来源的APC在GVL应答中占主导地位，尽管随着肿瘤负荷的急剧下降，供体APC也有贡献。
Graft-versus-leukemia ( GVL) response after allogeneic bone marrow transplantation ( BMT) represents one of the most potent forms of immunotherapy against malignant diseases(1). Antigen-presenting cells ( APCs) are crucial for the induction of graft-versus-host disease ( GVHD)(2-6), the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.