Comparison of Positron Emission Tomography Measurement of Adenosine-Stimulated Absolute Myocardial Blood Flow Versus Relative Myocardial Tracer Content for Physiological Assessment of Coronary Artery Stenosis Severity and Location
Comparison of Positron Emission Tomography Measurement of Adenosine-Stimulated Absolute Myocardial Blood Flow Versus Relative Myocardial Tracer Content for Physiological Assessment of Coronary Artery Stenosis Severity and Location
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DOI：
10.1016/j.jcmg.2009.04.004
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发表时间：
2009-06-01
影响因子：
14
通讯作者：
Gewirtz, Henry
中科院分区：
文献类型：
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作者：
Hajjiri, Mohammad M.;Leavitt, Marcia B.;Gewirtz, Henry
目的：本研究验证了腺苷（Ado）刺激心肌血流量（MBFado）的绝对测量优于相对示踪剂摄取测量的假设，以识别血流动力学显著的冠状动脉疾病（CAD）。与Ado期间相对示踪剂含量（TC） （nCi/ml）的测量相比，正电子发射断层扫描测量Ado期间绝对心肌血流量（MBF） （n -13-氨）能够更准确地评估CAD的血流动力学严重程度，根据定义，TC至少依赖于一个正常区，与其他正常区进行比较。方法选取已知或疑似CAD患者27例（男性20例，58 +/- 11岁，平均+/- SD）和正常患者21例（男性13例，38 +/- 10岁）。对参数化（K1） MBF图像和TC sum图像进行分析。狭窄bb0 = 70%定义为显著CAD。接受者-操作者特征曲线（ROC）分析曲线下面积（AUC）比较MBF和TC结果。对敏感性、特异性和准确性的切点分析显示，MBF诊断CAD的最佳标准是mbfa
OBJECTIVES This study tests the hypothesis that absolute measurement of adenosine (Ado)stimulated myocardial blood flow (MBFado) is superior to measurement of relative tracer uptake for identification of hemodynamically significant coronary artery disease (CAD).BACKGROUND Positron emission tomography measurement of absolute myocardial blood flow (MBF) (N-13-ammonia) with Ado has the capability to more accurately assess hemodynamic severity of CAD than measurement of relative tracer content (TC) (nCi/ml) during Ado, which by definition depends on at least 1 normal zone to which others are compared.METHODS A total of 27 patients (20 male, 58 +/- 11 years, mean +/- SD) with known or suspected CAD and 21 normal subjects (13 male, 38 +/- 10 years) were studied. Parametric (K1) MBF images and TC sum images were analyzed. A stenosis >= 70% defined significant CAD. The receiver-operator characteristic curve (ROC) analysis area under the curve (AUC) compared MBF and TC results. Cut-point analysis for sensitivity, specificity, and accuracy showed the best MBF criteria for CAD as MBFado