Effects of QDs exposure on the reproductive and embryonic developmental toxicity in mice at various pregnancy stages
Effects of QDs exposure on the reproductive and embryonic developmental toxicity in mice at various pregnancy stages
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量子点暴露对不同妊娠阶段小鼠生殖和胚胎发育毒性的影响
DOI：
10.1093/toxres/tfaa034
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发表时间：
2020-07-01
影响因子：
2.1
通讯作者：
Xu, Hengyi
中科院分区：
文献类型：
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作者：
Chen, Ling;Zheng, Fengxia;Xu, Hengyi
量子点具有独特的光学性质，近年来在生物医学领域引起了极大的关注。然而，关于它们对健康的影响，特别是对生殖系统的影响的信息有限。本研究旨在探讨静脉注射硫化镉/硫化锌量子点对妊娠不同阶段小鼠生殖系统和胚胎发育的影响。妊娠小鼠静脉注射的CdSe/ZnS量子点在母体肝脏、子宫和胎盘中蓄积。这种积累影响了妊娠早期和中期胚胎的生长和发育。此外，与氧化应激和细胞凋亡相关的基因表达水平增加，与营养和废物运输相关的基因表达水平降低，证明了镉/锌量子点对胎盘的遗传毒性。基因表达水平的改变阻碍了代谢物通过胎盘的运输，这反过来又影响了胎儿获得营养的能力。
Quantum dots (QDs) have recently attracted considerable attention in the biomedical fields because of their unique and excellent optical properties. However, information on their health effects, particularly in the reproductive system, is limited. The present study focuses on the effects of intravenous injection of CdSe/ZnS QDs on the reproductive system and embryo development at various stages of pregnancy in mice. The CdSe/ZnS QDs intravenously injected in mice during pregnancy accumulated in the maternal liver, uterus and placenta. This accumulation affected the growth and development of the embryo during the early and middle stages of pregnancy. Moreover, genotoxicity to the placenta after exposure to CdSe/ZnS QDs was demonstrated by the increased expression levels of genes related to oxidative stress and apoptosis and the reduced expression levels of genes related to the nutrient and waste transportation. Alterations in the gene expression levels have hindered the transport of metabolites across the placenta, which in turn affected the ability of the fetus to obtain nutrients.