The Impact of Alcohol Use on Antiretroviral Therapy Adherence in Koreans Living with HIV
The Impact of Alcohol Use on Antiretroviral Therapy Adherence in Koreans Living with HIV
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DOI：
10.1016/j.anr.2018.10.002
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发表时间：
2018-12-01
影响因子：
2.2
通讯作者：
Kim, Hyun Kyung
中科院分区：
文献类型：
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作者：
Kim, Ji Young;Yang, Youngran;Kim, Hyun Kyung
目的：本研究的目的是探讨酒精的使用对抗逆转录病毒治疗（ART）坚持韩国人的生活与人类免疫缺陷病毒（HIV）。方法：共144名艾滋病毒感染的韩国人年龄大于19岁谁一直接受抗逆转录病毒药物至少3个月进行了调查。根据韩国酒精使用障碍识别测试（AUDIT-K），酒精使用被确定为无害、狂欢、有害和酒精依赖。ART依从性根据依从性动机、依从性知识和使用改良Morisky量表的95%药物依从性的组成部分定义。收集的数据进行了分析，使用logistic回归分析的治疗adherence.Results的每个组件：在所有参与者中，13.9%的酗酒者，17.4%的危险饮酒者，4.2%的酒精依赖。对于低依从性动机，危险饮酒者的比值比为7.47 [95%置信区间（CI）：1.72-32.41; p = 0.007]，酒精依赖者的比值比为12.61（95% CI：1.38-115.38; p = 0.025）。对于药物依从性低于95%的患者，酗酒者的优势比为4.65（95% CI：1.15-18.92; p = .032），危险饮酒者为8.05（95% CI：2.08-31.20; p = .003），酒精依赖者为27.67（95% CI：2.12-360.51; p = .011）。建议韩国机构和政府制定具体的调解和咨询方案，包括酒精使用-开展相关监测，以提高艾滋病毒感染者坚持抗逆转录病毒疗法的情况。(C)2018年韩国护理科学学会，由Elsevier Korea LLC出版。
Purpose: This study aimed to examine the impact of alcohol use on the antiretroviral therapy (ART) adherence of Koreans living with human immunodeficiency virus (HIV).Methods: A total of 144 HIV-infected Koreans older than the age of 19 years who had been receiving antiretroviral drugs for at least 3 months were surveyed. Alcohol use was identified as nonhazardous, binge, hazardous, and alcohol dependent as determined by the Alchol Use Disorder Identification TestKorea (AUDIT-K). ART adherence was defined according to the components of adherence motivation, adherence knowledge, and 95% medication adherence using the modified Morisky scale. Collected data were analyzed using logistic regression analysis for each component of therapy adherence.Results: Of all participants, 13.9% were binge drinkers, 17.4% were hazardous drinkers, and 4.2% were alcohol dependent. For low adherence motivation, the odds ratio for the hazardous drinkers was 7.47 [95% confidence interval (CI): 1.72-32.41; p = .007] and for the alcohol dependent, it was 12.61 (95% CI: 1.38-115.38; p = .025) when compared with the nonhazardous drinkers. For medication adherence under 95%, the odds ratio for binge drinkers was 4.65 (95% CI: 1.15-18.92; p = .032), for hazardous drinkers was 8.05 (95% CI: 2.08-31.20; p = .003), and for the alcohol dependent was 27.67 (95% CI: 2.12-360.51; p = .011).Conclusion: It is recommended that Korean institutions and governments develop specific mediation and counseling programs that include alcohol use-related monitoring for the improvement of the ART adherence of people living with HIV. (C) 2018 Korean Society of Nursing Science, Published by Elsevier Korea LLC.