Mitochondrial permeability transition pore: Back to the drawing board
Mitochondrial permeability transition pore: Back to the drawing board
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DOI：
10.1016/j.neuint.2017.06.010
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发表时间：
2018-07-01
影响因子：
4.2
通讯作者：
Chinopoulos, Christos
中科院分区：
文献类型：
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作者：
Chinopoulos, Christos
当前关于线粒体通透性转变 (mPT) 孔组成的理论模型暗示了 ATP 合酶复合物的 c 亚基环。然而，最近的两项研究，一项是关于原子模拟，另一项是破坏 c 亚基编码的所有基因，反驳了这些模型。因此，孔隙的结构元素仍然未知。本简短回顾的目的是 (i) 简要回顾最新发现，(ii) 作为有关 mPT 细节的更全面回顾的索引，(iii) 重申在结合生物能量学研究 mPT 时的潜在陷阱，最重要的是 (iv) 建议那些寻找 mPT 孔隙特性的人也去其他地方寻找。 (C) 2017 Elsevier Ltd. 保留所有权利。
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere. (C) 2017 Elsevier Ltd. All rights reserved.