Increased brain apparent diffusion coefficient in tuberous sclerosis
Increased brain apparent diffusion coefficient in tuberous sclerosis
复制标题
DOI：
10.1148/radiol.2322030198
复制
发表时间：
2004-08-01
期刊：
影响因子：
19.7
通讯作者：
Simonetti, G
中科院分区：
文献类型：
--
作者：
Garaci, FG;Floris, R;Simonetti, G
目的：评价结节性硬化症患者与对照组相比，外观正常的白质（NAWM）的水扩散率。材料与方法：对18例临床确诊结节性硬化症患者（男10例，女8例，平均年龄20.1岁，范围12-30岁）和18例年龄匹配的对照组（男9例，女9例，平均年龄20.2岁，范围11-28岁）进行弥散和常规磁共振（MR）成像检查。产生表观扩散系数（adc），并在病灶周围的NAWM和远离错构瘤病变的NAWM的六个解剖位置手动放置小的椭圆区域。将病灶周围adc与对侧大脑同一解剖部位adc进行比较（广义线性回归分析）。将患者预定部位的adc与对照组进行比较（广义线性回归分析）。结果：结节性硬化症患者的幕上adc高于对照组，枕部白质、额部白质、半瓣膜体、顶叶白质和辐射冠的adc差异有统计学意义（各部位P < 0.001）。与对侧相同解剖位置的NAWM相比，病灶周围的NAWM也显著增加（P < 0.001）。幕下adc正常。结论：幕上NAWM的ADC显著升高。(c) rsna， 2004年。
PURPOSE: To evaluate the water diffusivity of normal-appearing white matter (NAWM) in patients with tuberous sclerosis complex compared with that in control subjects.MATERIALS AND METHODS: Diffusion and conventional magnetic resonance (MR) imaging examinations were performed in 18 patients with clinically established tuberous sclerosis complex (10 male and eight female patients; mean age, 20.1 years; range, 12-30 years), as well as in 18 age-matched control subjects (nine male and nine female; mean age, 20.2 years; range, 11-28 years). Apparent diffusion coefficients (ADCs) were generated, and small elliptic regions of interest were manually placed both in perilesional NAWM and in six anatomic locations of NAWM remote from hamartomatous lesions. Perilesional ADCs were compared with those at the same anatomic site on the contralateral side of the brain (generalized linear regression analysis). ADCs from the predetermined sites in patients were compared with those in control subjects (generalized linear regression analysis).RESULTS: Supratentorial ADCs were higher in patients with tuberous sclerosis complex than in control subjects, and statistically significant differences were observed in the occipital white matter, frontal white matter, centrum semiovale, parietal white matter, and corona radiata (for each location, P < .001). Significant increases were also seen in the perilesional NAWM compared with NAWM at the same anatomic locations on the contralateral side (P < .001). Infratentorial ADCs were normal.CONCLUSION: Significant ADC increases were measured in the supratentorial NAWM. (C) RSNA, 2004.