Sodium intake is increased by social stress and the Y chromosome and reduced by clonidine.
Sodium intake is increased by social stress and the Y chromosome and reduced by clonidine.
复制标题
社会压力和 Y 染色体会增加钠的摄入量，可乐定会减少钠的摄入量。
DOI：
10.1152/ajpregu.2000.278.2.r407
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Milsted,A
中科院分区：
文献类型：
--
作者：
Ely,D;Herman,M;Ely,L;Barrett,L;Milsted,A
The objectives were to determine1) if female rats have higher Na intake than males and if social stress increases Na intake,2) if the sympathetic nervous system (SNS) mediates the stress effects and the gender effect, and3) if the Y chromosome (Yc) from a hypertensive father increases Na intake. Four rat strains (n= 10/group) of both sexes were used:1) Wistar Kyoto normotensive (WKY),2) an F16backcross with a Yc from a hypertensive father (SHR/y),3) spontaneously hypertensive rat (SHR), and4) an F16backcross with a Yc from a normotensive father (SHR/a). Females showed greater baseline Na intake than males (hypertensive strains), intruder stress increased Na intake, and clonidine decreased Na intake, but not in WKY or SHR females. SHR/y males had higher baseline Na intake compared with WKY males. In conclusion, the higher Na intake in females during baseline and stress was partially mediated through the SNS in hypertensive strains and the SHR Yc was partially responsible for the increased Na intake in SHR/y and SHR males compared with WKY.
