Experience-dependent and independent binocular correspondence of receptive field subregions in mouse visual cortex.
Experience-dependent and independent binocular correspondence of receptive field subregions in mouse visual cortex.
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DOI：
10.1093/cercor/bht027
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发表时间：
2014-06
期刊：
影响因子：
3.7
通讯作者：
R. Sarnaik;Bor-Shuen Wang;Jianhua Cang
中科院分区：
文献类型：
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作者：
R. Sarnaik;Bor-Shuen Wang;Jianhua Cang
眼睛特异性丘脑输入到视皮层神经元的会聚形成了双眼视觉的基础。来自同一只眼睛的信号光增量（开）和减量（关）的输入在空间上被分离成子区域，从而产生对刺激方向有选择性的皮层感受野（RF）。在这里，我们映射的双眼神经元的RF在小鼠初级视觉皮层使用尖峰触发的平均。我们发现，相同的符号（开-开和关-关）的子区域优先重叠之间的2个单眼RF，导致双目匹配的方向调整。我们进一步证明，这种子区域的对应关系和随之而来的匹配的RF方向被破坏的小鼠饲养在黑暗中发展。令人惊讶的是，尽管缺乏所有出生后的视觉经验，相当程度的次区域对应仍然存在。此外，黑暗饲养的小鼠显示正常的单眼RF结构和双眼重叠。因此，这些结果揭示了经验依赖和独立的过程中的双眼收敛和细化的开和关输入到单个皮层神经元的具体作用。
The convergence of eye-specific thalamic inputs to visual cortical neurons forms the basis of binocular vision. Inputs from the same eye that signal light increment (On) and decrement (Off) are spatially segregated into subregions, giving rise to cortical receptive fields (RFs) that are selective for stimulus orientation. Here we map RFs of binocular neurons in the mouse primary visual cortex using spike-triggered average. We find that subregions of the same sign (On-On and Off-Off) preferentially overlap between the 2 monocular RFs, leading to binocularly matched orientation tuning. We further demonstrate that such subregion correspondence and the consequent matching of RF orientation are disrupted in mice reared in darkness during development. Surprisingly, despite the lack of all postnatal visual experience, a substantial degree of subregion correspondence still remains. In addition, dark-reared mice show normal monocular RF structures and binocular overlap. These results thus reveal the specific roles of experience-dependent and -independent processes in binocular convergence and refinement of On and Off inputs onto single cortical neurons.