Development of a Novel, Nearly Insoluble Antiadhesive Membrane
Development of a Novel, Nearly Insoluble Antiadhesive Membrane
复制标题
DOI：
10.1159/000333093
复制
发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
Tani, T.
中科院分区：
文献类型：
--
作者：
Mukai, T.;Kamitani, S.;Tani, T.
背景：透明质酸钠/羧甲基纤维素（HA/CMC）由于其对水分的敏感性而难以在潮湿环境中使用。方法：我们开发了三层nDM-14 R膜。表面层由1-丙交酯、乙交酯和e-己内酯共聚物组成。在所有这些研究中使用HA/CMC和nDM-14 R。(1)将1 × 10 cm试样（n = 5）的中心区域润湿0、5、10、20、30或60 s，之后测定拉伸强度;（2）将1 × 10 cm的样品（n = 5）的一侧用琼脂凝胶润湿5、10、15或30秒，之后测定粘附强度，和（3）刮擦大鼠盲肠（n = 10），将3 × 3cm的样本放置在刮擦区域上，并在术后第14天评价粘连。结果与结论：（1）nDM-14 R与HA/CMC接触10-30 s后的拉伸强度大于HA/CMC。(2)HA/CMC在接触5-10 s后的粘合强度大于nDM-14 R。(3)治疗组的粘连评分显著低于对照组。结果表明，nDM-14 R具有相同的抗粘连效果，并且在潮湿条件下比HA/CMC更容易放置。版权所有（C）2011 S. Karger AG，巴塞尔
Background: Sodium hyaluronate/carboxymethylcellulose (HA/CMC) is difficult to use in a moist environment because of its susceptibility to moisture. Methods: We developed the three-layered nDM-14R membrane. The surface layers are composed of 1-lactide, glycolide and e-caprolactone copolymers. HA/CMC and nDM-14R were used in all these studies. (1) The central region of 1 x 10 cm specimens (n = 5) was moistened for 0, 5, 10, 20, 30 or 60 s, after which the tensile strength was determined; (2) one side of specimens of 1 x 10 cm (n = 5) was moistened with agar gel for 5, 10, 15 or 30 s, after which the adhesion strength was determined, and (3) Rat cecum (n = 10) was scratched, 3 x 3 cm specimens were placed on the scratched area, and adhesions were evaluated on postoperative day 14. Results and Conclusion: (1) The tensile strength of nDM-14R after contact for 10-30 s was greater than that of HA/CMC. (2) The adhesive strength of HA/CMC after contact for 5-10 s was greater than that of nDM-14R. (3) Adhesion scores in treatment groups were significantly lower than in the control group. The results suggest that nDM-14R has the same antiadhesive effect and allows easier placement under moist conditions than HA/CMC. Copyright (C) 2011 S. Karger AG, Basel