Generating quiescent stem cells.
Generating quiescent stem cells.
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DOI：
10.1111/j.1600-0749.2007.00388.x
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发表时间：
2007-08
期刊：
影响因子：
--
通讯作者：
S. Nishikawa;M. Osawa
中科院分区：
文献类型：
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作者：
S. Nishikawa;M. Osawa
随着检测和定义干细胞（SCs）能力的提高，人们的注意力转向了生态位的定义和诱导SC静止或增殖的信号的识别。在黑素细胞干细胞-生态位系统中，SCs及其后代占据毛囊内地理位置不同的区域，为研究环境线索和支撑细胞命运的转录因子之间复杂的相互作用提供了最好的模型之一。本文讨论了已知的黑素细胞SCs的起源和分子特征，并提出了一系列可能有助于在毛囊中建立黑素细胞SCs的时间事件。我们还强调了体外系统的可能性，该系统能够根据特定的外部因素将培养的黑素细胞/黑素母细胞引导到SC命运。
As the ability to detect and define stem cells (SCs) has increased, attention is turning towards the definition of the niche and the identification of the signals that induce SC quiescence or proliferation. The melanocyte stem-niche system, in which the SCs and their progeny occupy geographically distinct domains within the hair follicle, provides one of the best models for studying the complex interplay between environmental cues and transcription factors that underpin cell fate. This review discusses what is known of the origin and molecular characteristics of melanocyte SCs and proposes a series of temporal events that are likely to contribute to the establishment of melanocyte SCs in the hair follicle. We also highlight the possibility of in vitro systems capable of directing cultured melanocytes/melanoblasts to a SC fate in response to specific extrinsiccues.