Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)
Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)
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DOI：
10.1016/j.jbiomech.2008.10.006
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发表时间：
2009-03-11
影响因子：
2.4
通讯作者：
Yamaguchi, Takami
中科院分区：
文献类型：
--
作者：
Shimogonya, Yuji;Ishikawa, Takuji;Yamaguchi, Takami
我们提出了一个新的脑动脉瘤发生的血流动力学指标，该指标由作用于内皮细胞的张力/压缩力的时间波动来定义。我们采用了患者特定的颈内动脉(ICA)的几何形状，并通过人工切除动脉瘤重建了动脉瘤形成前的ICA几何形状。我们使用计算流体力学技术计算了所建议的血流动力学指数和其他五个血流动力学指数(收缩峰值时的壁切应力(WSS)、时间平均的WSS、时间平均的空间WSS梯度、振荡剪切指数(OSI)和潜在的动脉瘤形成指标(AFI))。通过比较各指标在动脉瘤形成部位的分布情况，探讨各指标的有效性。结果表明，只有建议的血流动力学指标与动脉瘤形成的位置有显著的相关性。我们的发现表明，建议的指数可能是有用的血流动力学指标，以启动脑动脉瘤。(C)2008爱思唯尔有限公司。保留所有权利。
We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms. (c) 2008 Elsevier Ltd. All rights reserved.