The epidemiology of infantile spasms
The epidemiology of infantile spasms
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DOI：
10.1017/s0317167100001517
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发表时间：
2001-11-01
影响因子：
3
通讯作者：
Wood, EP
中科院分区：
文献类型：
--
作者：
Brna, PM;Gordon, KE;Wood, EP
目的：本研究的目的是估计婴儿痉挛症（IS）的人群发病率，并研究我们的临床印象，即IS的发病率最近在加拿大新斯科舍省和爱德华王子岛省有所下降。方法：出生队列从1978年至1998年，确定通过医院的健康记录，脑电图记录和医生计算机化的数据库，进行了为期两年的发展是。疾病发病率的计算使用的是加拿大统计局报告的年活产率。结果：75例患者符合IS的入选标准。IS的总体发生率为30.7/100，000例活产（95% CI 24.3，38.8）。病因分类为症状性51例（68%），隐源性18例（24%），特发性6例（8%）。尽管男性（N=44）多于女性（N=31），但发病率相似。年发病率和五年发病率有显著差异。结论：虽然我们的患者的临床特征与其他报道的IS人群相似，但IS发病率的不稳定性表明在解释较小的IS流行病学研究时需要谨慎。
Objective: The aim of this study was to estimate population based incidence rates for infantile spasms (IS) and to study our clinical impression that the incidence of IS has recently decreased in the Canadian Provinces of Nova Scotia and Prince Edward Island. Methods: Birth cohorts from 1978 to 1998, identified through the hospital health records, EEG records and physician computerized databases, were followed for two years for the development of IS. Disease incidence rates were calculated using denominators derived from Statistics Canada's reported annual live birth rates. Results: The inclusion criteria for IS were fulfilled by 75 patients. The overall incidence of IS was 30.7/100,000 live births (95% CI 24.3, 38.8). Etiologic classification was symptomatic for 51 cases (68%), cryptogenic for 18 (24%), and idiopathic in six children (8%). Although there were more males (N=44) than females (N=31), the incidence rates were similar. There was a marked variability in annual and five-year incidence rates. Conclusions: Although the clinical characteristics of our patients were similar to other reported IS populations, the instability in IS incidence rates indicates a need for caution in interpreting smaller IS epidemiologic studies.