Fundus autofluorescence patterns in eyes with primary intraocular lymphoma.
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma.
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DOI：
10.1097/iae.0b013e3181b408a2
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Mochizuki M
中科院分区：
文献类型：
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作者：
Ishida T;Ohno-Matsui K;Kaneko Y;Tobita H;Shimada N;Takase H;Mochizuki M
探讨原发性眼内（玻璃体视网膜）淋巴瘤（PIOL/PVRL）患者眼底自发荧光（FAF）模式。回顾了在国家眼科研究所（NEI）接受FAF成像的所有PIOL患者的记录。根据临床疾病状态和荧光素血管造影（FA）和光谱域光学相干断层扫描（SD-OCT）图像的结果评价FAF模式。有18只眼（10例患者）PIOL接受了FAF成像。11眼（61%）可见颗粒状高、低自体荧光，2眼（11%）可见肿块阻塞。所有FAF上有颗粒图案的眼睛在成像时都有活动性PIOL，但有5只FAF不明显的眼睛被发现有活动性淋巴瘤。FA上最常见的模式是低荧光圆形斑点与“豹点”外观（43%）。在5只（36%）眼睛中，FA上的这些低荧光点与FAF上的高自体荧光点相关（FAF倒置）。OCT检查发现43%的患眼在RPE水平出现结节状高反射斑。FAF上的高自体荧光斑点与OCT上的结节状高反射斑点相关6只眼（43%）。在大多数情况下，眼底自发荧光颗粒与活动性淋巴瘤相关。在不到一半的眼睛中观察到FAF倒置（FAF上的超自体荧光点对应于FA上的低荧光点）。
To evaluate fundus autofluorescence (FAF) patterns in patients with primary intraocular (vitreoretinal) lymphoma (PIOL/PVRL). Records of all PIOL patients who underwent FAF imaging at the National Eye Institute (NEI) were reviewed. FAF patterns were evaluated with respect to clinical disease status and the findings on fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) images. There were 18 eyes (10 patients) with PIOL who underwent FAF imaging. Abnormal autofluorescence in the form of granular hyper- and hypoautofluorescence was seen in 11 eyes (61%) and blockage by mass lesion was seen in 2 eyes (11%). All eyes with granular pattern on FAF had active PIOL at the time of imaging, but there were 5 eyes with unremarkable FAF which were found to have active lymphoma. The most common pattern on FA was hypofluorescent round spots with a “leopard-spot” appearance (43%). These hypofluorescent spots on FA correlated to hyperautofluorescent spots on FAF in 5 (36%) eyes (inversion of FAF). Nodular hyperreflective spots at the level of RPE on OCT were noted in 43% of eyes. The hyperautofluorescent spots on FAF correlated with nodular hyperreflective spots on OCT in 6 eyes (43%). Granularity on fundus autofluorescence was associated with active lymphoma in majority of cases. An inversion of FAF (hyperautofluorescent spots on FAF corresponding to hypofluorescent spots on FA) was observed in less than half of the eyes.