Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs.
Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs.
复制标题
辣椒素和肺部过度充气刺激小直径的肺传入纤维。
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
J. Luck
中科院分区：
文献类型：
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作者：
H. Coleridge;J. Coleridge;J. Luck
本文描述了实验中，冲动已记录从传入迷走神经纤维的末梢位于肺。这些纤维与Adrian（1933）和随后的工作者描述的肺牵张纤维不同，因为它们的自发活动稀疏且不规则，在正常通气量下没有呼吸调节。然而，通过使肺膨胀更大的体积来刺激纤维。纤维似乎直径较小，平均传导速度为1 - 6 m/sec，阻断温度为1-6° C。这些缓慢传导的纤维以下列方式鉴定。辣椒素是香草胺的癸烯酸酰胺，静脉注射会产生心动过缓、全身性低血压和呼吸暂停（Toh，Lee & Kiang，1955; Porszasz，Such & Porszasz-Gibiszer，1957）。Porsztasz等人（1957）认为，刺激肺动脉肺外部分的压力感受器反射性地诱发了这三种效应。随后，Coleridge，Coleridge & Kidd（1964）发现，虽然肺动脉压力感受器无疑在介导反射效应中起作用，但肺本身血管床内的一些其他传入末梢可能也参与其中。因此，对辣椒素刺激的肺内受体进行了研究。本文中所描述的传入纤维在这项工作的过程中遇到的。它们是唯一持续受到辣椒素刺激的肺纤维，辣椒素对Adrian（1933）描述的肺牵张纤维的活性几乎没有影响。
This paper describes experiments in which impulses have been recorded from afferent vagal fibres whose endings were located in the lung. These fibres differed from the pulmonary stretch fibres described by Adrian (1933) and subsequent workers in that their spontaneous activity was sparse and irregular and showed no respiratory modulation at normal ventilation volumes. The fibres were stimulated, however, by inflating the lungs with larger volumes. The fibres appeared to be of small diameter, having a mean conduction velocity of 16 m/sec and a blocking temperature of 1-6° C. These slowly conducting fibres were identified in the following way. Capsaicin, a decylenic acid amide of vanillylamine, injected intravenously produces bradyeardia, systemic hypotension and apnoea (Toh, Lee & Kiang, 1955; Porsz6asz, Such & Porszasz-Gibiszer, 1957). Porsztasz et al. (1957) suggested that this triad of effects was evoked reflexly by stimulation of baroreceptors in the extrapulmonary parts of the pulmonary artery. Subsequently, Coleridge, Coleridge & Kidd (1964) found that although pulmonary arterial baroreceptors undoubtedly played a part in mediating the reflex effects, some other afferent endings within the vascular bed of the lung itself were probably involved. A search was therefore made for intrapulmonary receptors which were stimulated by capsaicin. The afferent fibres described in the present paper were encountered in the course of this work. They were the only pulmonary fibres consistently stimulated by capsaicin, the drug having little or no effect on the activity of pulmonary stretch fibres of the type described by Adrian (1933).