Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.
Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process.
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第四维中的策略和模型构建：基因型X年龄相互作用的无效模型，作为高斯固定随机过程。
DOI：
10.1186/1471-2156-4-s1-s34
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发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
Blangero, J
中科院分区：
文献类型：
--
作者：
Diego, VP;Almasy, L;Dyer, TD;Soler, JMP;Blangero, J
采用单变量和多变量方差分量连锁分析方法，我们研究了来自心脏研究的与衰老过程相关的心血管表型中可能的基因型×年龄交互作用。我们发现了空腹血糖和收缩压的基因型×年龄相互作用的证据。空腹血糖和收缩压存在多基因基因型×年龄相互作用，而收缩压表型的连锁信号存在数量性状基因座×年龄相互作用，位于17号染色体67 cM处。
Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype × age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. We found evidence for genotype × age interaction for fasting glucose and systolic blood pressure. There is polygenic genotype × age interaction for fasting glucose and systolic blood pressure and quantitative trait locus × age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.