Identification of Y Chromosome Genetic Variations in Chinese Indigenous Horse Breeds
Identification of Y Chromosome Genetic Variations in Chinese Indigenous Horse Breeds
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DOI：
10.1093/jhered/esq047
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发表时间：
2010-09-01
影响因子：
3.1
通讯作者：
Mahmut, Halik
中科院分区：
文献类型：
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作者：
Ling, Yinghui;Ma, Yuehui;Mahmut, Halik
Y染色体作为一个单一的非重组单位，是男性特有的，实际上是单倍体的，因此确保突变事件作为单一单倍型通过雄性系保存。本研究利用6个Y染色体特异微卫星(SSR)对中国家马(30个品种)、普氏野马和驴的573个雄性样本的父系遗传变异进行了检测。这6个基因座在普氏马和家驴中均表现为单倍型。然而，在Y染色体标记上，马和驴之间存在显著差异。Eca有2种单倍型。YA16在国内马种中为单倍型A(等位基因A：156个碱基)和单倍型B(等位基因B：152个碱基)。A等位基因是30个马种中常见的等位基因，B等位基因在11个马种中存在。这是对马的Y染色体变异的第一次描述。在中国所发现的国内马种中发现的两种Y染色体单倍型有助于揭示其复杂的遗传谱系。
Y chromosome acts as a single nonrecombining unit that is male specific and in effect haploid, thus ensuring the preservation of mutational events as a single haplotype via male lines. In this study, 6 Y chromosome-specific microsatellites (SSR) were tested for the patrilineal genetic variations of 573 male samples from Chinese domestic horse (30 breeds), Przewalski's horse, and donkey. All the 6 loci appeared as a haplotype block in Przewalski's horse and the domestic donkey. There were notable differences, however, at Y chromosome markers between horse and donkey. There were 2 haplotypes of Eca. YA16 in the domestic horse breeds, Haplotype A (Allele A: 156 bp) and Haplotype B (Allele B: 152 bp). Allele A was the common allele among 30 horse breeds, and Allele B was found in 11 horse breeds. This is the first description of a Y chromosome variant for horses. The 2 haplotypes of Y chromosome discovered in the domestic horse breeds in China could be helpful in unveiling their intricate genetic genealogy.