INDUCTION OF HTLV-III LAV FROM A NONVIRUS-PRODUCING T-CELL LINE - IMPLICATIONS FOR LATENCY
INDUCTION OF HTLV-III LAV FROM A NONVIRUS-PRODUCING T-CELL LINE - IMPLICATIONS FOR LATENCY
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DOI：
10.1126/science.3003906
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发表时间：
1986-02-07
期刊：
影响因子：
56.9
通讯作者：
FAUCI, AS
中科院分区：
文献类型：
--
作者：
FOLKS, T;POWELL, DM;FAUCI, AS
When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, by treatment with 5-iodo-2''-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.
