Costs and benefits of high mutation rates: Adaptive evolution of bacteria in the mouse gut
Costs and benefits of high mutation rates: Adaptive evolution of bacteria in the mouse gut
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DOI：
10.1126/science.1056421
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发表时间：
2001-03-30
期刊：
影响因子：
56.9
通讯作者：
Taddei, F
中科院分区：
文献类型：
--
作者：
Giraud, A;Matic, I;Taddei, F
我们已经证明，细菌突变率在小鼠肠道的实验性定植过程中发生了变化。高突变率最初是有益的，因为它允许更快的适应，但一旦实现适应，这一好处就消失了。突变子细菌积累了突变。虽然在小鼠的肠道中是中性的，但在次级环境中往往是有害的。突变子细菌在传播到类似宿主和重新定居期间的竞争力一直在下降。突变细菌的短期优势和长期劣势可以解释它们在自然界中的出现频率。
We have shown that bacterial mutation rates change during the experimental colonization of the mouse gut. A high mutation rate was initially beneficial because it allowed faster adaptation, but this benefit disappeared once adaptation was achieved. Mutator bacteria accumulated mutations that. although neutral in the mouse gut, are often deleterious in secondary environments. Consistently, the competitiveness of mutator bacteria is reduced during transmission to and re-colonization of similar hosts. The short-term advantages and long-term disadvantages of mutator bacteria could account for their frequency in nature.