The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.
The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.
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DOI：
10.1139/cjpp-2014-0401
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发表时间：
2015-04
影响因子：
2.1
通讯作者：
Y. Lytvyn;J. Wan;V. Lai;Pinchas Cohen;D. Cherney
中科院分区：
文献类型：
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作者：
Y. Lytvyn;J. Wan;V. Lai;Pinchas Cohen;D. Cherney
与男性相比，糖尿病(DM)与女性肾脏和血管保护的丧失有关，但其责任机制尚不清楚。最近的实验工作表明人素(HN)是一种新的糖尿病细胞保护性激素。我们的目标是测量无并发症的1型糖尿病患者(T1D)和健康对照组(HC)中HN水平的性别差异，以及HN、循环神经激素和血管功能之间的相互作用。在夹闭正常血糖(4~6mmol.L(-1))时，分别测定HC(男11例，女10例)和T1D(男23例，女18例)的血浆HN、cGMP、醛固酮、血压、肾小球滤过率和有效肾血浆流量(菊粉和对氨基马尿酸)。与女性相比，HC男性的血浆HN水平普遍较低，但差异无统计学意义。相反，与T1D女性(p=0.026)和HC男性(p<；0.0001)相比，T1D男性的水平更高。在HC男性中，HN与血压呈负相关，但与肾功能、cGMP或醛固酮无关。在T1D组，HN与血浆cGMP呈负相关。在T1D妇女中，HN与神经激素或血管功能无关。未来的工作应确定HN在糖尿病性别相关血管功能差异的发病机制中的作用。
Diabetes mellitus (DM) is associated with a loss of renal and vascular protection in women compared with men, but the responsible mechanisms are unclear. Recent experimental work implicated humanin (HN) as a novel cytoprotective hormone in DM. Our goal was to measure sex-related differences in HN levels in uncomplicated type 1 DM patients (T1D) and healthy controls (HC), as well as the interaction between HN, circulating neurohormones, and vascular function. Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)). Plasma HN levels were generally lower in HC men by comparison with the women, but the differences were not statistically significant. In contrast, levels in the T1D men were higher compared with the T1D women (p = 0.026) and HC men (p < 0.0001). In the HC men, but not the women, HN correlated negatively with BP, but not with renal function, cGMP, or aldosterone. In the T1D men, HN negatively correlated with plasma cGMP. In the T1D women, HN did not correlate with neurohormones or vascular function. Future work should determine the role of HN in the pathogenesis of sex-related vascular function differences in DM.