Effect of age on vanadium nephrotoxicity in rats
Effect of age on vanadium nephrotoxicity in rats
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DOI：
10.1016/s0378-4274(98)00385-3
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发表时间：
1999-03-08
影响因子：
3.5
通讯作者：
Domingo, JL
中科院分区：
文献类型：
--
作者：
de la Torre, A;Granero, S;Domingo, JL
本研究旨在评估大鼠静脉注射钒酸盐后钒肾毒性的潜在年龄相关性差异。幼龄(22日龄)和成年(62日龄)雄性SD大鼠接受腹腔注射。注射原钒酸钠10 mg/kg/d，连续8天。另外两组对照组大鼠接受腹腔注射。在同一时期注射0.9%的生理盐水。在幼年和成年大鼠中，用作肾毒性指标的大多数参数都存在显著的年龄差异，随着年龄的增长，不利的肾脏影响更加严重。钒引起的肾脏的形态变化也随着年龄的增长而更加明显。这些发现与用钒酸盐处理的成年大鼠组比未用钒酸盐处理组的成年大鼠肾中钒的浓度更高是一致的。如果在未来，钒化合物可以用于糖尿病患者的治疗，目前的结果可能会令人担忧。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
The present study was designed to assess potential age dependent differences of vanadium nephrotoxicity in the rat following parenteral administration of vanadate. Young (22 days) and adult (62 days) male Sprague-Dawley rats received i.p. injections of sodium orthovanadate at 10 mg/kg/day for 8 consecutive days. Two additional groups of control rats received i.p. injections of 0.9% saline during the same period. Significant age-differences were found in most of the parameters used as indicators of nephrotoxicity in young and adult rats, with adverse renal effects being more severe with age. Vanadium-induced morphologic changes in the kidney were also more pronounced with age. These findings agree with a higher renal concentration of vanadium in the group of adult rats treated with vanadate than in the vanadate-untreated group. The current results can be of concern if in the future, vanadium compounds can be administered in the treatment of diabetic patients. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.