Smooth muscle relaxation and local hydraulic impedance properties of the aorta.
Smooth muscle relaxation and local hydraulic impedance properties of the aorta.
复制标题
主动脉的平滑肌松弛和局部液压阻抗特性。
DOI：
10.1152/jappl.2001.90.6.2427
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Shroff,SG
中科院分区：
文献类型：
--
作者：
Cholley,BP;Lang,RM;Korcarz,CE;Shroff,SG
Smooth muscle relaxation is expected to yield beneficial effects on hydraulic impedance properties of large vessels. We investigated the effects of intravenous diltiazem infusion on aortic wall stiffness and local hydraulic impedance properties. In seven anesthetized, closed-chest dogs, instantaneous cross-sectional area and pressure of the descending thoracic aorta were measured using transesophageal echocardiography combined with acoustic quantification and a micromanometer, respectively. Data were acquired during a vena caval balloon inflation, both at the control condition and with diltiazem infusion. At the operating point, diltiazem reduced blood pressure in all dogs but did not alter aortic dimensions or wall stiffness. Over the observed pressure range, aortic area-pressure relationships were linear. Whereas diltiazem affected the slope of this relationship variably (no change in 3 dogs, increase in 1 dog, decrease in 3 dogs), the zero-pressure area intercept was significantly increased in every case such that higher area was observed at any given pressure. When comparisons were made at a common level of wall stress, wall stiffness was either increased or unchanged during diltiazem infusion. In contrast, diltiazem decreased wall stiffness in every case when comparisons were made at a common level of aortic midwall radius. Aortic characteristic impedance and pulse wave velocity, components of left ventricular hydraulic load that are determined by aortic elastic and geometric properties, were affected variably. A comparison of wall stiffness at matched wall stress appears inappropriate for assessing changes in smooth muscle tone. Because of the competing effects of changes in vessel diameter and wall stiffness, smooth muscle relaxation is not necessarily accompanied by the expected beneficial changes in local aortic hydraulic impedance. These results can be reconciled by recognizing that components other than vascular smooth muscle (e.g., elastin, collagen) contribute to aortic wall stiffness.
登录
查看更多内容
通过具有反向散射成像和横向增益补偿的超声心动图自动在线量化左心室尺寸和功能。
DOI：
10.1016/0002-9149(92)90056-5
发表时间：
1992
期刊：
The American journal of cardiology
影响因子：
--
作者：
Pérez,JE;Klein,SC;Prater,DM;Fraser,CE;Cardona,H;Waggoner,AD;Holland,MR;Miller,JG;Sobel,BE
通讯作者：
Sobel,BE
地尔硫卓对狗主动脉压力-直径关系的影响。
影响因子：
--
作者：
M. Yano;T. Kumada;Masunori Matsuzaki;M. Kohno;T. Hiro;S. Kohtoku;T. Miura;K. Katayama;M. Ozaki;Reizo Kusukawa
通讯作者：
Reizo Kusukawa
主动脉平滑肌对完整狗静脉回流变化的反应性质。
影响因子：
--
作者：
G. Nicolosi;H. P. Pieper
通讯作者：
H. P. Pieper
动脉顺应性在人类高血压生理药理学方法中的作用
影响因子：
3
作者：
A. Simon;J. Levenson;N. Chau;I. Pithois
通讯作者：
I. Pithois
狗的主动脉压力和直径的关系。
影响因子：
3.3
作者：
G. O. Barnett;A. J. Mallos;A. Shapiro
通讯作者：
A. Shapiro