Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis.
Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis.
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实验室在确保全球访问HIV感染儿童的ARV治疗方面的作用：关于早期婴儿诊断实验室测定的共识声明。
DOI：
10.2174/1874613600802010017
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Nkengasong JN
中科院分区：
文献类型：
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作者：
Stevens W;Sherman G;Downing R;Parsons LM;Ou CY;Crowley S;Gershy-Damet GM;Fransen K;Bulterys M;Lu L;Homsy J;Finkbeiner T;Nkengasong JN
世界卫生组织 (WHO) 和美国疾病控制与预防中心 (CDC) 于 2006 年 5 月在乌干达恩德培主办了为期两天的会议，审查病毒分子方法的实验室性能，特别是罗氏 Amplicor DNA PCR 1.5 版检测在婴儿 HIV-1 感染诊断中的性能。来自 17 个国家的约 60 名与会者出席了会议。关于不同环境和 HIV 亚型的 9 个 HIV/艾滋病高负担非洲国家的 HIV-1 DNA PCR 检测的性能和局限性的数据被共享。制定了关于使用该检测进行早期婴儿诊断的共识声明，并确定了需要进行操作研究的领域。此外，对于儿童时期干血斑 (DBS) 标本作为确保儿科人群更容易获得血清学和病毒学 HIV 检测的手段的有用性达成了共识。
A two day meeting hosted by the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) was held in May 2006 in Entebbe, Uganda to review the laboratory performance of virologic molecular methods, particularly the Roche Amplicor DNA PCR version 1.5 assay, in the diagnosis of HIV-1 infection in infants. The meeting was attended by approximately 60 participants from 17 countries. Data on the performance and limitations of the HIV-1 DNA PCR assay from 9 African countries with high-burdens of HIV/AIDS were shared with respect to different settings and HIV- subtypes. A consensus statement on the use of the assay for early infant diagnosis was developed and areas of needed operational research were identified. In addition, consensus was reached on the usefulness of dried blood spot (DBS) specimens in childhood as a means for ensuring greater accessibility to serologic and virologic HIV testing for the paediatric population.