Anti-riboflavin activity of 8-O-alkyl derivatives of riboflavin in some Gram-positive bacteria.
Anti-riboflavin activity of 8-O-alkyl derivatives of riboflavin in some Gram-positive bacteria.
复制标题
核黄素 8-O-烷基衍生物在某些革兰氏阳性菌中的抗核黄素活性。
DOI：
10.3177/jnsv.25.289
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发表时间：
1979
影响因子：
1.6
通讯作者：
K. Matsui
中科院分区：
文献类型：
--
作者：
S. Kasai;S. Yamanaka;S. C. Wang;K. Matsui
两种新的核黄素（RF）的8-O-烷基衍生物，合成了8-甲氧基-（MOF）、8-乙氧基-8-去甲基-D-核黄素（HAF）、它们的四乙酸酯和8-羟基-8-去甲基-D-核黄素的四乙酸酯（霍夫）。根据CR/CI比率估计MOF、BAF和霍夫的抗RF活性，其中CI是添加到培养基中的测试黄素的浓度，CR是恢复生长抑制所需的RF的最小浓度。并与玫瑰黄素（RoF）的活性进行了比较。抗RF活性的降低顺序为：八叠球菌中MOF> RoF> ERF;蜡样芽孢杆菌和金黄色葡萄球菌中RoF> MOF> ERF。霍夫在任何测试的细菌中都没有显示出活性。这些化合物的氧化还原电位的变化规律如下：RF大于RoF大于NH3大于MOF大于霍夫，并且MOF和NH3的RF活性可以通过这些化合物与RF之间的氧化还原电位差来解释。
Two new 8-O-alkyl derivatives of riboflavin (RF), i.e., 8-methoxy- (MOF), and 8-ethoxy-8-demethyl-D-riboflavin (EOF), their tetraacetate, and the tetraacetate of 8-hydroxy-8-demethyl-D-riboflavin (HOF) were synthesized. The anti-RF activity of MOF, EOF and HOF was estimated from the ratio CR/CI, where CI is the concentration of test flavin added to the culture medium and CR is the minimum concentration of RF needed to restore the growth inhibition. Their activity was also compared with that of roseoflavin (RoF). The decreasing order of anti-RF activity was as follows: MOF greater than RoF greater than EOF in Sarcina lutea: RoF greater than MOF greater than EOF in Bacillus cereus and Staphylococcus aureus. HOF showed no activity in any of the bacteria tested. The redox potential of these compounds decreases as follows: RF greater than RoF greater than EOF greater than MOF greater than HOF, and the RF activity of MOF and EOF could be explained by the redox potential difference between these compounds and RF.