Maternal schizophrenia and pregnancy outcome: Does the use of antipsychotics make a difference?
Maternal schizophrenia and pregnancy outcome: Does the use of antipsychotics make a difference?
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DOI：
10.1016/j.schres.2009.10.011
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发表时间：
2010-01-01
影响因子：
4.5
通讯作者：
Wu, Fang-Jen
中科院分区：
文献类型：
--
作者：
Lin, Herng-Ching;Chen, I-Ju;Wu, Fang-Jen
目的：本研究比较了在妊娠期间接受典型、非典型和无抗精神病药物治疗的精神分裂症母亲的不良妊娠结局风险，包括早产、低出生体重（LBW）、大胎龄（LGA）和小胎龄（SGA）。他们都与对照subjects.Methods：我们使用的是基于人口的数据，从台湾全民健康保险研究数据库和出生证明登记处，涵盖了2001年至2003年。总共有696名患有精神分裂症的母亲和3480名匹配的未受影响的母亲被纳入分析。在调整了母亲、父亲和婴儿的特征后，进行了多变量logistic回归分析，以检查LBW、早产、SGA和LGA的风险，比较精神分裂症母亲和未受影响的母亲。在调整了潜在的混杂因素后，未患病母亲LBW和SGA的比值分别为0.72（95% CI = 0.50-0.88）和0.81（95% CI = 0.64-0.92）倍。与妊娠期间接受非典型抗精神病药物治疗的精神分裂症母亲和未接受抗精神病药物治疗的精神分裂症母亲相比，LBW、早产、LGA和SGA婴儿的风险无显著差异。然而，母亲与精神分裂症在怀孕期间接受典型的抗精神病药物有较高的几率早产（OR = 2.46，95%CI = 1.50-4.11）相比，那些不接受抗精神病药物Conclusions：数据表明，精神分裂症的母亲LBW和SGA的风险不受抗精神病药物的使用。在怀孕期间接受典型抗精神病药物治疗的妇女早产的风险略高。(C)2009 Elsevier B. V.保留所有权利。
Objective: This study compared the risk of adverse pregnancy outcome-including preterm births, low birth weight (LBW), large-gestational-age (LGA), and small-gestational-age (SGA)-among mothers with schizophrenia receiving typical, atypical, and no antipsychotics during pregnancy. They were all compared with control subjects.Methods: We used population-based data from the Taiwan National Health Insurance Research Database and birth certificate registry covering the years 2001 to 2003. In total, 696 mothers with schizophrenia and 3480 matched unaffected mothers were included for analysis. After adjusting for characteristics of mother, father, and infants, multivariate logistic regression analyses were performed to examine the risk of LBW, preterm gestation, SGA, and LGA, comparing mothers with schizophrenia and unaffected mothers.Results: After adjusting for potential confounders, the odds of LBW and SGA for unaffected mothers respectively were 0.72 (95% Cl = 0.50-0.88) and 0.81 (95% Cl = 0.64-0.92) times those of mothers with schizophrenia who had not receiving antipsychotics during pregnancy. There was no significant difference in the risk of LBW, preterm births, LGA, and SGA babies compared to mothers with schizophrenia receiving atypical antipsychotics during pregnancy and those not receiving antipsychotics. However, mothers with schizophrenia receiving typical antipsychotics during pregnancy had higher odds of preterm birth (OR = 2.46, 95% Cl = 1.50-4.11) compared to those not receiving antipsychotics.Conclusions: The data suggest that the risks for LBW and SGA among mothers with schizophrenia are not affected by antipsychotic use. Women who receive treatment with typical antipsychotics during pregnancy are at slightly higher risk of preterm birth. (C) 2009 Elsevier B.V. All rights reserved.