Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Computational design of virus-like protein assemblies on carbon nanotube surfaces.
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DOI：
10.1126/science.1198841
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发表时间：
2011-05-27
期刊：
影响因子：
--
通讯作者：
DeGrado WF
中科院分区：
文献类型：
--
作者：
Grigoryan G;Kim YH;Acharya R;Axelrod K;Jain RM;Willis L;Drndic M;Kikkawa JM;DeGrado WF
There is a general need for engineering of protein-like molecules that organize into geometrically-specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multi-layered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recognition and favorable inter-subunit packing interactions. This procedure is exemplified in the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes (SWNTs). The geometrically-defined, virus-like coating created by these peptides converts the smooth surfaces of SWNTs into highly textured assemblies, with long-scale order, capable of directing the assembly of gold nanoparticles into helical arrays along the SWNT axis.
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影响因子：
5.6
作者：
Grigoryan G;Degrado WF
通讯作者：
Degrado WF
影响因子：
56.9
作者：
Dahiyat, BI;Mayo, SL
通讯作者：
Mayo, SL
影响因子：
56.9
作者：
O'Connell, MJ;Bachilo, SM;Smalley, RE
通讯作者：
Smalley, RE
影响因子：
2.9
作者：
Calhoun, JR;Nastri, F;DeGrado, WF
通讯作者：
DeGrado, WF
DOI：
10.1073/pnas.0404387101
发表时间：
2004-08-10
影响因子：
11.1
作者：
Kaplan, J;DeGrado, WF
通讯作者：
DeGrado, WF