Simvastatin improves spinal fusion in rats
Simvastatin improves spinal fusion in rats
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DOI：
10.3944/aott.2011.2526
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发表时间：
2011-07-01
影响因子：
1
通讯作者：
Erkorkmaz, Unal
中科院分区：
文献类型：
--
作者：
Bostan, Bora;Gunes, Taner;Erkorkmaz, Unal
目的：他汀类药物通过诱导骨形态发生蛋白（BMP-2）的表达促进骨形成。本研究的目的是探讨口服辛伐他汀对大鼠脊柱融合的影响。方法：将20只大鼠随机分为脊柱融合组（SF）（n=10）和脊柱融合加口服辛伐他汀组（SFS）（n=10）。在代表两个节段的L4-L 6之间进行脊柱融合。SFS组给予辛伐他汀（120 mg/kg/d）口服。在12周的研究periods.Results：手动触诊显示两个中度融合SF组结束时，大鼠被杀死。SFS组未发现任何假关节迹象。SFS和SF组导致融合失败的平均三点弯曲力分别为148.80 +/- 39.403牛顿和123.80 +/- 28.479牛顿（p>0.05）。组织学检查显示SFS组的融合等级（平均值：9.30 +/- 0.949）优于SF组（平均值：6.80 +/- 2.044）（p=0.003）。影像学检查显示SF组2个节段C级融合，18个节段A级融合。在SFS组中，1个节段出现C级融合，19个节段出现A级融合。结论：辛伐他汀可促进脊柱融合，可作为高胆固醇老年人群脊柱融合术的辅助治疗。
Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats.Methods: Twenty rats were randomized into a spinal fusion group (SF) (n=10) or a spinal fusion and oral simvastatin administered group (SFS) (n=10). A spinal fusion was performed between L4-L6 representing two levels. Simvastatin (120 mg/kg/day) was administered orally in the SFS group. The rats were killed at the end of the 12 week study period.Results: Manual palpation revealed two moderate fusions in the SF group. The SFS group did not reveal any signs of pseudoarthrosis. An average three-point bending force causing failure of fusion revealed results of 148.80 +/- 39.403 Newtons and 123.80 +/- 28.479 Newtons in SFS and SF groups, respectively (p>0.05). Histological examination revealed better fusion grades in the SFS group (mean: 9.30 +/- 0.949) than in the SF group (mean: 6.80 +/- 2.044) (p=0.003). Radiographic examination revealed Grade C fusion in two levels and Grade A fusion in 18 levels in the SF group. In the SFS group, Grade C fusion was detected in one level and Grade A fusions in 19.Conclusion: Our results suggest that simvastatin can promote spinal fusion and can be used as an adjunct to spinal fusion procedures in an elderly population with high cholesterol levels.