The readily releasable pool of synaptic vesicles.
The readily releasable pool of synaptic vesicles.
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DOI：
10.1016/j.conb.2016.12.012
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发表时间：
2017-04
影响因子：
5.7
通讯作者：
Regehr WG
中科院分区：
文献类型：
--
作者：
Kaeser PS;Regehr WG
每一个突触前终扣都被许多小泡紧密包裹，其中只有一小部分可立即释放。这些囊泡构成了易释放池（RRP）。RRP大小和RRP内每个囊泡释放的概率一起决定突触强度。在这里，我们讨论的并发症和最近的进展，在确定的大小生理相关的RRP。我们认为分子机制产生和调节RRP，并讨论囊泡对接和RRP之间的关系。我们的结论是，许多RRP囊泡停靠，一些停靠囊泡可能不是RRP的一部分，和未停靠囊泡可以通过快速招聘到未被占用的，分子激活的准备torelease网站的RRP作出贡献。
Each presynaptic bouton is densely packed with many vesicles, only a small fraction of which are available for immediate release. These vesicles constitute the readily releasable pool (RRP). The RRP size, and the probability of release of each vesicle within the RRP, together determine synaptic strength. Here, we discuss complications and recent advances in determining the size of the physiologically relevant RRP. We consider molecular mechanisms to generate and regulate the RRP, and discuss the relationship between vesicle docking and the RRP. We conclude that many RRP vesicles are docked, that some docked vesicles may not be part of the RRP, and that undocked vesicles can contribute to the RRP by rapid recruitment to unoccupied, molecularly activated ready-torelease sites.