[Koi herpesvirus disease].
[Koi herpesvirus disease].
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DOI：
10.2222/jsv.55.145
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发表时间：
2005-06-01
期刊：
影响因子：
--
通讯作者：
Sano, Motohiko
中科院分区：
文献类型：
--
作者：
Iida, Takaji;Sano, Motohiko
锦鲤疱疹病毒（KHV）病出现于20世纪90年代末，并迅速蔓延到世界各地。在日本，KHV病于2003年10月首次发生。该病导致野生鲤鱼和养殖鲤鱼大量死亡。到目前为止，日本47个县中有42个发现了感染KHV的鲤鱼。只有鲤鱼对KHV敏感，而金鱼，与鲤鱼密切相关的物种，则不敏感。受影响的鲤鱼游得无精打采。经常注意到眼睛凹陷和鳃坏死，但没有观察到明显的内部体征。最佳水温为18-23摄氏度。低于13摄氏度或超过28摄氏度，不会发生死亡。保持在30摄氏度以上可以治愈KHV病，但会使鱼成为潜伏的携带者。由于在低水温条件下，鱼对KHV病没有获得性免疫力，随着水温的升高，该病会复发。KHV的隔离是困难的。通过流行病学调查、疾病体征和PCR检测KHV DNA来诊断KHV病。正在开发疫苗，以便在受KHV污染的地方重新开始养殖鲤鱼。
Koi herpesvirus (KHV) disease emerged at the late 1990s, and has rapidly spread to the world. In Japan, KHV disease first occurred at October 2003. The disease resulted in mass mortality of wild carp as well as cultured carp. Until now, KHV-infected carp were found in 42 out of 47 prefectures in Japan. Only carp Cyprinus carpio is susceptible to KHV, while goldfish, closely-related species to carp, is not. The affected carp swim lethargically. Sunken eyes and gill necrosis are frequently noticed, but no marked internal signs are observed. Optimal water temperature for the disease is 18-23 degrees C. Under 13 degrees C or over 28 degrees C, no death occurs. Keep at over 30 degrees C cures KHV disease, but can make the fish latent carriers. Because the fish do not get acquired immunity against KHV disease under low water temperature, the disease recurs with increase of water temperature. Isolation of KHV is difficult. KHV disease is diagnosed through epidemiological investigation, disease signs and PCR detection of KHV DNA. Vaccine development is ongoing for restart of culturing carp at KHV-contaminated places.