Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification.
Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification.
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呼吸暂停小鼠模型：呼吸暂停表达的菌株差异及其药理学和遗传修饰。
DOI：
10.1007/978-1-4419-5692-7_62
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发表时间：
2010
影响因子：
--
通讯作者：
Strohl,KingmanP
中科院分区：
文献类型：
--
作者：
Yamauchi,Motoo;Kimura,Hiroshi;Strohl,KingmanP
小鼠缺氧后通气行为存在品系差异，C57BL/ 6j （B6）小鼠在急性缺氧暴露后的再充氧过程中出现不规则呼吸，包括呼吸暂停，而A/J小鼠则没有。B6小鼠对缺氧-复氧循环的反应是人类睡眠呼吸暂停综合征的模拟，这一现象使我们将B6小鼠视为睡眠呼吸暂停的动物模型。此外，与A/J小鼠相比，B6小鼠更倾向于出现自发性呼吸暂停和呼吸后呼吸暂停。在这篇简短的综述中，我们提出的证据表明，药物治疗和基因改造可以改善包括B6呼吸暂停在内的不规则呼吸，这表明这些药物治疗可能对不能耐受nCPAP的睡眠呼吸暂停患者有效。此外，我们关于基因差异和修饰的发现应该有助于探索睡眠呼吸暂停的发病机制。
Mouse strain differences exist in post-hypoxic ventilatory behavior, specifically, the C57BL/6 J (B6) mouse exhibits irregular breathing including apnea during re-oxygenation after acute hypoxic exposure, while A/J mouse does not. This phenomenon of the B6 mouse responding to the hypoxia-reoxygenation cycle which is a mimic of human sleep apnea syndrome let us consider the B6 mouse as an animal model of sleep apnea. Moreover, the B6 mouse tends to show spontaneous apnea and post-sigh apnea compared to the A/J mouse. In this brief review, we present evidence that pharmacologic approaches as well as genetic modification can improve irregular breathing including apnea in the B6, suggesting that these pharmacologic treatment might be effective for the patients with sleep apnea who cannot tolerate nCPAP. Moreover our findings regarding genetic difference and modification should be helpful to explore the pathogenesis of sleep apnea.