Muscle biopsy and muscle fiber hypercontraction: a brief review.
Muscle biopsy and muscle fiber hypercontraction: a brief review.
复制标题
肌肉活检和肌纤维过度收缩：简要回顾。
DOI：
10.1007/s004210000287
复制
发表时间：
2000
影响因子：
3
通讯作者：
Rogers,MA
中科院分区：
文献类型：
--
作者：
Roth,SM;Martel,GF;Rogers,MA
经皮肌肉活检技术是运动和应用生理学研究人类骨骼肌结构、适应和再生的重要工具。这项技术的一个重要用途是评估超微结构肌肉损伤，特别是在剧烈运动方案后获得的组织样本中，通常涉及离心肌肉动作。在这篇简短的评论中，我们定义和描述了过度收缩的纤维，并概述了这些纤维如何对固定组织造成的肌肉损伤的解释产生不利影响。有证据表明，健康骨骼肌样本中存在的过度收缩纤维可能是与肌肉活检过程相关的伪影，而不是活检之前存在的内在变性。当过度收缩的纤维被认为是肌肉样本固有的（例如，在肌病中或在极端偏心刺激后）时，这种纤维通常与炎症细胞的浸润有关，表明再生反应。相反，活检过程产生的过度收缩纤维通常与炎症反应无关。概述了过度收缩纤维的主要来源，并讨论了对其解释的建议。
The percutaneous muscle biopsy technique is an important tool used in exercise and applied physiology to study human skeletal muscle structure, adaptation, and regeneration. One important use of this technique has been the assessment of ultrastructural muscle damage, especially in tissue samples obtained following strenuous exercise protocols, often involving eccentric muscle actions. In this brief review, we define and describe hypercontracted fibers, and outline how such fibers may adversely affect the interpretation of muscle damage from fixed tissue. Evidence suggests that hypercontracted fibers present in healthy skeletal muscle samples are likely to be artifacts related to the muscle biopsy procedure, as opposed to intrinsic degeneration present prior to the biopsy. When hypercontracted fibers are noted as being intrinsic to a muscle sample (e.g., in myopathy or following an extreme eccentric stimulus), such fibers are generally associated with the infiltration of inflammatory cells, indicative of a regenerative response. In contrast, hypercontracted fibers resulting from the biopsy procedure are not typically associated with an inflammatory response. The major sources of hypercontracted fibers are outlined and recommendations for their interpretation are discussed.
家族性脊髓灰质炎、线粒体肌病和乳酸血症
影响因子：
9.9
作者：
Y. Shapira;S. Cederbaum;P. Cancilla;D. Nielsen;B. Lippe
通讯作者：
B. Lippe
影响因子：
19.7
作者：
BOTTOMLEY, PA;HERFKENS, RJ;BASHORE, TM
通讯作者：
BASHORE, TM
一种线粒体脑肌病，伴有肌肉部分细胞色素 C 氧化酶缺乏。
DOI：
10.1136/jnnp.51.5.704
发表时间：
1988
期刊：
Journal of Neurology, Neurosurgery & Psychiatry
影响因子：
--
作者：
P. M. van Erven;F. Gabreëls;W. Ruitenbeek;W. Renier;H. T. ter Laak;A. Stadhouders
通讯作者：
A. Stadhouders