Improving Solute Clearances by Hemodialysis.

Improving Solute Clearances by Hemodialysis.
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通过血液透析提高溶质清除率。

DOI:
10.1159/000524512
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发表时间:
2022-05-25
期刊:
影响因子:
3
通讯作者:
--
中科院分区:
医学4区
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--
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血液透析的充分性现在通过测量单溶质尿素的清除来评估。当代透析提供的尿素清除率是通过透析器的血流的很大一部分,因此不能进一步增加。然而,其他溶质可能比尿素更容易导致血液透析患者的残余尿毒症。我们在这里审查的方法,可用于增加非尿素溶质的清除。我们将分别考虑游离低分子量溶质、游离较大溶质和蛋白结合溶质的清除率。需要进行新的临床研究来测试增加具有这些不同特征的非尿素溶质的清除率可以改善患者健康的程度。
The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be required to test the extent to which increasing the clearance on nonurea solutes with these various characteristics can improve patients' health.
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