Severity of periodontal disease and number of remaining teeth are related to the prevalence of myocardial infarction and hypertension in a study based on 4,254 subjects
Severity of periodontal disease and number of remaining teeth are related to the prevalence of myocardial infarction and hypertension in a study based on 4,254 subjects
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DOI：
10.1902/jop.2006.050233
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发表时间：
2006-07-01
影响因子：
4.3
通讯作者：
Lind, Lars
中科院分区：
文献类型：
--
作者：
Holmlund, Anders;Holm, Gunnar;Lind, Lars
背景资料：在过去的15年中，越来越多的证据表明牙周病和心血管疾病之间的关联已在流行病学研究中提出。本研究的目的是调查牙周病的严重程度和剩余牙齿的数量与心肌梗死（MI）和高血压（HT）的关系。方法：收集自我报告的HT和MI的历史，在3,352例牙周科，耶夫勒县医院，并在902例从普通人群中随机选择。牙周炎的严重程度通过全口X线检查中每颗牙齿周围的骨质流失量、探诊时有无出血（BOP）以及分叉病变的发生来评估。（患病率16%; P < 0.0005），即使调整了总样本中的年龄、性别、牙齿数量和吸烟情况，（患病率1.7%，P < 0.03），但仅在中年（40 ~ 60岁）人群中。患病牙周袋数仅与HT相关（P < 0.0001），经上述调整后，这种关系仍然存在。牙齿的数量与MI（P < 0.03），即使校正后的年龄，性别和吸烟，但不相关的高血压。结论：牙周病的严重程度与HT独立的年龄，但在中年受试者的MI的患病率。病变囊袋的数量仅与HT显著相关。另一方面，牙齿数量与MI的患病率相关，与年龄无关，但与HT无关。这些数据支持口腔健康与心血管疾病呈剂量依赖关系的观点。
Background: During the past 15 years, mounting evidence for the association between periodontal and cardiovascular disease has been presented in epidemiological studies. The aim of this study was to investigate how the severity of periodontal disease and number of remaining teeth relates to myocardial infarction (MI) and hypertension (HT).Methods: Self-reported history of HT and MI was collected in 3,352 patients referred to the Department of Periodontology, Gavle County Hospital, and in 902 subjects randomly selected from the general population. Severity of periodontitis was estimated by a combination of the amount of bone loss around each tooth investigated from a full-mouth x-ray, the presence or absence of bleeding on probing (BOP), and involvement of furcations.Results: The severity of periodontitis was significantly associated with HT (prevalence 16%; P < 0.0005), even after adjustment for age, gender, number of teeth, and smoking in the total sample, and with MI (prevalence 1.7%, P < 0.03) after above-mentioned adjustments, but in middle-aged (40 to 60 years) subjects only. The number of diseased periodontal pockets was related to HT only (P < 0.0001), and this relationship remained after the above-mentioned adjustments. The number of teeth was associated with MI (P < 0.03) even after correction for age, gender, and smoking but was not related to hypertension.Conclusions: The severity of periodontal disease was related to HT independent of age but to the prevalence of MI in middle-aged subjects only. The number of diseased pockets was significantly related to HT only. On the other hand, the number of teeth was associated with the prevalence of MI independent of age but not to HT. These data support the view that oral health is related to cardiovascular disease in a dose-dependent manner.