Evaluation of Carotid Plaque Neovascularization in Patients With Coronary Heart Disease on Contrast-Enhanced Ultrasonography
Evaluation of Carotid Plaque Neovascularization in Patients With Coronary Heart Disease on Contrast-Enhanced Ultrasonography
复制标题
超声造影评价冠心病患者颈动脉斑块新生血管
DOI：
10.1002/jum.14410
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发表时间：
2018-04-01
影响因子：
2.3
通讯作者：
Xie, Mingxing
中科院分区：
文献类型：
--
作者：
Qin, Chuan;Zhang, Li;Xie, Mingxing
目的探讨超声造影定量分析颈动脉斑块内新生血管的时间-强度曲线的可重复性，探讨冠心病患者颈动脉斑块新生血管的形成及其危险因素与急性冠脉综合征（ACS）的相关性。方法：60例ACS患者和60例稳定型冠心病（CAD）患者行常规颈动脉造影和增强造影，观察斑块增强情况并定量分析。颈动脉造影增强超声在ACS发生1个月内进行。评估了观测者间和观测者内的测量变异性。峰值信号强度为局部组织所能积聚的造影剂微泡的最大数量，反映局部微血管密度，代表毛细血管体积。结果：ACS组低密度脂蛋白胆固醇升高(平均+/- SD分别为3.21 +/- 0.75和2.53 +/- 0.71 mmol/L
Objectives-To examine the repeatability of quantitative time-intensity curve analysis of neovascularization within carotid plaques with contrast-enhanced ultrasonography (US) and to investigate carotid plaque neovascularization in patients with coronary heart disease using contrast-enhanced US and the correlation between risk factors and acute coronary syndrome (ACS).Methods-Sixty patients with ACS and 60 with stable coronary artery disease (CAD) underwent conventional carotid and contrast-enhanced US, and plaque enhancement was observed and analyzed quantitatively. Carotid contrast-enhanced US was performed within 1 month of ACS occurrence. Interobserver and intraobserver variability of the measurements was assessed. The peak signal intensity was the maximum number of contrast microbubbles that local tissues could accumulate, reflecting the local microvascular density and representing the capillary volume.Results-The ACS group had higher low-density lipoprotein cholesterol (mean +/- SD, 3.21 +/- 0.75 versus 2.53 +/- 0.71 mmol/L; P