Age-related Infertility
Age-related Infertility
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DOI：
10.1016/j.ogc.2014.09.005
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发表时间：
2015-03-01
影响因子：
3.2
通讯作者：
Steiner, Anne Z.
中科院分区：
文献类型：
--
作者：
Crawford, Natalie M.;Steiner, Anne Z.
卵母细胞数量和质量随年龄增长而下降。因此，生育能力随着年龄的增长而下降，在35岁以后下降得更快。35岁以上的患者应在尝试受孕不超过6个月后立即接受不孕原因的评估。卵巢储备检查异常的患者预后较差，可能需要更迅速和积极的治疗。虽然卵子捐赠是克服年龄相关性不孕症的最佳方法，但其他治疗选择可能会帮助女性更快地怀孕。高龄患者在接受不孕症治疗前应接受咨询和评估。
Oocyte number and quality decrease with advancing age. Thus, fecundity decreases as age increases, with a more rapid decline after the mid-30s. Patients more than 35 years old should receive prompt evaluation for causes of infertility after no more than 6 months of attempted conception. Patients with abnormal tests of ovarian reserve have a poorer prognosis and may need more expedited and aggressive treatment. Although oocyte donation is the best method to overcome age-related infertility, other treatment options may help women proceed quicker toward pregnancy. Patients at an advanced age should be counseled and evaluated before undergoing infertility treatments.