Role of Magnesium and the Effect of Surface Roughness on the Hydroxyapatite-Forming Ability of Zirconia Induced by Biomimetic Aqueous Solution Treatment
Role of Magnesium and the Effect of Surface Roughness on the Hydroxyapatite-Forming Ability of Zirconia Induced by Biomimetic Aqueous Solution Treatment
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DOI：
10.3390/ma13143045
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发表时间：
2020-07-01
期刊：
影响因子：
3.4
通讯作者：
Sakaguchi, Hiroshi
中科院分区：
文献类型：
--
作者：
Zamin, Hasnat;Yabutsuka, Takeshi;Sakaguchi, Hiroshi
由于其机械和美学特性，氧化锆是一种众所周知的牙科和骨科应用的生物陶瓷。然而，它缺乏足够的生物活性来与活骨结合。本研究旨在通过简单的仿生水溶液处理诱导四方氧化锆多晶（3Y-TZP）的生物活性。首先，用氢氟酸（HF）蚀刻提高3Y-TZP表面的粗糙度。然后，用两种含钙和磷酸盐离子的水溶液（Ca-P溶液）处理样品；一种溶液含有镁离子，另一种不含镁离子。最后，通过常规模拟体液（SBF）试验评价羟基磷灰石（HAp）的形成能力，并研究了Mg离子对羟基磷灰石层对粗化3Y-TZP表面粘附强度的影响。结果表明，Mg离子对HAp形成能力的影响无显著差异，两种溶液处理在SBF浸泡1 d后均能形成致密的HAp。然而，与不含Mg离子的Ca-P溶液相比，在其中一种Ca-P溶液中掺入Mg离子显著提高了HAp层对hf蚀刻3Y-TZP衬底的粘附强度。
Zirconia is a well-known bioceramic for dental and orthopedic applications due to its mechanical and aesthetic properties. However, it lacks sufficient bioactivity to bond with the living bone. This study was aimed to induce bioactivity to tetragonal zirconia polycrystal (3Y-TZP) by simple biomimetic aqueous solution treatment. First, hydrofluoric acid (HF) etching was performed to enhance the surface roughness of the 3Y-TZP surface. Then, the samples were treated with two types of aqueous solutions containing calcium and phosphate ions (Ca-P solutions); one solution additionally contained magnesium (Mg) ions and the other without Mg ions. Finally, hydroxyapatite (HAp)-forming ability was evaluated by the conventional simulated body fluid (SBF) test, and the effect of Mg ions on the adhesive strength of the HAp layer to the roughened 3Y-TZP surface was also investigated. The results concluded that there were no noticeable differences in the effect of Mg ions on the HAp-forming ability, and both types of solution treatments resulted in dense HAp formation in 1 day SBF immersion. However, incorporation of Mg ions in one of the Ca-P solutions significantly improved the adhesive strength of the HAp layer to the HF-etched 3Y-TZP substrate compared to the Ca-P solution with no Mg ions.