Coenzyme Q10 changes are associated with metabolic syndrome.
Coenzyme Q10 changes are associated with metabolic syndrome.
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辅酶 Q10 的变化与代谢综合征有关。
DOI：
10.1016/j.cccn.2004.02.016
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Pesce,AmadeoJ
中科院分区：
文献类型：
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作者：
Miles,MichaelV;Morrison,JohnA;Horn,PaulS;Tang,PeterH;Pesce,AmadeoJ
BackgroundThe本研究的目的是确定是否辅酶Q10（辅酶Q）浓度和氧化还原状态与代谢syndrome.MethodsThis的组成部分是一个横断面调查223成人（28-78岁），谁是从正在进行的普林斯顿随访研究在大辛辛那提。个人进行了评估肥胖，血压，血糖，血脂，C-反应蛋白（CRP），辅酶Q（泛醇），氧化辅酶Q（泛醌），总辅酶Q和辅酶Q氧化还原比（泛醇/泛醌）的措施。代谢综合征低危组和高危组的比较表明，高危组中辅酶Q氧化还原率增加（p<0.05）。以年龄、性别、种族、（ln）CRP、总胆固醇、LDL、泛醇、泛醌和总辅酶Q作为预测因子的逐步logistic回归分析显示，只有年龄（p=0.001），校正血脂后的总辅酶Q（p<0.0001）和（ln）CRP（p<0.005）的平均值。是代谢综合征的重要预测因子。结论代谢综合征组分的存在与血浆总辅酶Q和泛醇浓度调整后的年龄，性别和种族。辅酶Q氧化还原比的增加可能表明女性对氧化应激的性别特异性适应性反应，而不是男性。
BackgroundThe purpose of this study was to determine whether coenzyme Q10(CoQ) concentrations and redox status are associated with components of the metabolic syndrome.MethodsThis is a cross-sectional survey of 223 adults (28–78 years), who were drawn from the ongoing Princeton Follow-up Study in greater Cincinnati. Individuals were assessed for measures of fatness, blood pressure, glucose, lipid profiles, C-reactive protein (CRP), reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), total CoQ and CoQ redox ratio (ubiquinol/ubiquinone).ResultsAfter adjusting for age, sex and race, we found that total CoQ, ubiquinol and CRP levels are significantly increased in metabolic syndrome. Comparison of minimal risk and high-risk metabolic syndrome groups indicates an increased CoQ redox ratio in the high risk group (p<0.05). Step-wise logistic regression analysis, using age, sex, race, (ln)CRP, total cholesterol, LDL, ubiquinol, ubiquinone and total CoQ as predictors, shows that only age (p=0.001), total CoQ adjusted for plasma lipids (p<0.0001) and (ln)CRP (p<0.005) were significant predictors of metabolic syndrome.ConclusionsThe presence of metabolic syndrome components are associated with increased plasma total CoQ and ubiquinol concentrations after adjusting for age, sex and race. An increase in CoQ redox ratio may indicate a gender-specific adaptive response to oxidative stress in females, but not males.