Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task
Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task
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DOI：
10.1016/j.bbr.2006.03.033
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发表时间：
2006-08-10
影响因子：
2.7
通讯作者：
Prickaerts, Jos
中科院分区：
文献类型：
--
作者：
Blokland, Arjan;Rutten, Kris;Prickaerts, Jos
在本研究中，我们调查了空间导航雄性和雌性Wistar大鼠在Morris水逃逸任务。大鼠进行程序，需要使用的地方（地点），线索（CUE）和自我中心（EGO）的反应，以有效地学习任务。在第一个实验中，大鼠依次在PLACE、CUE和EGO条件下进行测试，在第二个实验中，任务顺序颠倒。第一个实验表明，在PLACE任务中，雌性大鼠游的距离更长，需要更多的时间来找到平台。此外，在探测试验期间，雌性大鼠在先前平台位置附近花费的时间少于雄性大鼠。CUE和EGO任务没有性别差异。在第二个实验中，在EGO任务中，雌性大鼠比雄性大鼠花更长的时间找到平台。在CUE和PLACE任务中，在获取过程中没有发现性别差异。然而，在PLACE任务的探测试验中，雄性大鼠比雌性大鼠在先前的平台位置附近花费更多的时间。根据目前的数据，可以得出结论，在雄性Wistar大鼠中使用基于位置的策略更好。CUE学习不依赖于性别。使用自我策略的能力似乎是没有不同的雄性和雌性Wistar大鼠，但似乎依赖于预暴露的任务。(c)2006 Elsevier B.V.保留所有权利。
In the present study we investigated spatial navigation in male and female Wistar rats in the Morris water escape task. Rats were subjected to procedures which required the use of a place (PLACE), cue (CUE) and egocentric (EGO) response to learn the task efficiently. In a first experiment rats were successively tested in the PLACE, CUE and EGO condition and in a second experiment the order of tasks was reversed. The first experiment showed that female rats swam longer distances and took more time to find the platform in the PLACE task. Further, the female rats spent less time near the previous platform position than the male rats during probe trial. No sex difference was found in the CUE and EGO task. In the second experiment, the female rats took longer to find the platform than the male rats in the EGO task. In the CUE and PLACE task no differences between the sexes was found during acquisition. However, the male rats spent more time near the previous platform position than the female rats during the probe trial of the PLACE task. On basis of present data it is concluded that the use of a PLACE-based strategy is better in male Wistar rats. CUE learning is not sex-dependent. The ability to use EGO strategies appears not to be different between male and female Wistar rats, but appears dependent on pre-exposure to the task. (c) 2006 Elsevier B.V. All rights reserved.