Neonatal vitamin D status at birth at latitude 32°72′:: evidence of deficiency
Neonatal vitamin D status at birth at latitude 32°72′:: evidence of deficiency
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DOI：
10.1038/sj.jp.7211796
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发表时间：
2007-09-01
影响因子：
2.9
通讯作者：
Hollis, B. W.
中科院分区：
文献类型：
--
作者：
Basile, L. A.;Taylor, S. N.;Hollis, B. W.
目的：由于维生素D缺乏是一个严重的公共卫生问题，在纬度32度72分的新生儿中测定了出生时维生素D状况。研究设计：在脐带血中，维生素D的状态，通过循环25-羟基维生素D来证明，被测量并与种族和出生季节相关。该队列的100份脐带血样本中25-羟基维生素D的平均值+/-标准差为13.5 +/- 8.3 ng/ ml。非裔美国婴儿的平均+/-标准差为10.5 +/- 6.0 ng/ ml，其维生素D水平明显低于白人婴儿，平均+/-标准差为19.5 +/- 9.6 ng/ ml（P < 0.0001）。按季节划分，出生时平均25-羟维生素D水平在11月3月相比，4月至10月是11.3 ng/ ml，白人婴儿（从29.0至17.7 ng/ ml）和3 ng/ ml，非洲裔美国婴儿（从13.1至10.1 ng/ ml）低。非洲裔美国婴儿在出生时的维生素D水平明显低于白人婴儿。季节性，而显着的两组，有一个更大的影响高加索新生儿的维生素D状态。
Objective: With vitamin D deficiency as a serious public health problem, vitamin D status at birth was measured in neonates at latitude 32 degrees 72 ' ( southeastern United States).Study Design: In umbilical cord blood, vitamin D status, demonstrated by circulating 25- hydroxyvitamin D, was measured and related to race and season of birth.Result: The mean +/- standard deviation of 25- hydroxyvitamin D in 100 cord blood samples was 13.5 +/- 8.3 ng/ ml for the cohort. African- American infants, with a mean +/- standard deviation of 10.5 +/- 6.0 ng/ ml, demonstrated significantly lower vitamin D status than Caucasian infants, with a mean +/- standard deviation of 19.5 +/- 9.6 ng/ ml ( P < 0.0001). By season, the mean 25- hydroxyvitamin D level at birth in November March compared to April - October was 11.3 ng/ ml lower in Caucasian infants ( from 29.0 to 17.7 ng/ ml) and 3 ng/ ml lower in African- American infants ( from 13.1 to 10.1 ng/ ml).Conclusion: The prevalence of vitamin D insufficiency is high in this cohort. African- American infants demonstrate significantly lower vitamin D status at birth than Caucasian infants. Seasonality, while significant in both groups, had a greater impact on the vitamin D status of Caucasian newborns.