Sex chromosome evolution in parasitic nematodes of humans
Sex chromosome evolution in parasitic nematodes of humans
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DOI：
10.1038/s41467-020-15654-6
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发表时间：
2020-04-23
影响因子：
16.6
通讯作者：
Ghedin, Elodie
中科院分区：
文献类型：
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作者：
Foster, Jeremy M.;Grote, Alexandra;Ghedin, Elodie
性别决定机制往往不同，甚至在相关的物种，但性染色体的进化仍然知之甚少，但在所有少数模式生物。一些线虫如秀丽隐杆线虫具有XO性别决定系统，而其他线虫如马来丝虫具有XY机制。我们提出了一个完整的B。malayi基因组拼接，并确定与C.线虫，然后我们映射到其他丝虫物种和更远的相关线虫的基因组。我们发现一个显着的可塑性，在性染色体的进化与几个不同的情况下，新的X和新的Y形成，X-添加的区域，和转换的常染色体的性染色体，我们提出了一个模型，染色体的进化跨越不同的线虫分支。线虫门提供了一个新的和创新的系统，以获得更深入的了解性染色体的进化。包括秀丽隐杆线虫在内的许多蠕虫都有XX/XO性别决定，而其他物种则有XY。作者使用一种新的马来丝虫基因组组装和已发表的数据表明，线虫性染色体进化是高度可塑的。
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution. Many nematode worms, including Caenorhabditis elegans have XX/XO sex determination, while other species have XY. The authors use a new genome assembly of the filarial parasite Brugia malayi and published data to show that nematode sex chromosome evolution is highly plastic.