HUMAN AND RAT TR4 ORPHAN RECEPTORS SPECIFY A SUBCLASS OF THE STEROID-RECEPTOR SUPERFAMILY
HUMAN AND RAT TR4 ORPHAN RECEPTORS SPECIFY A SUBCLASS OF THE STEROID-RECEPTOR SUPERFAMILY
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DOI：
10.1073/pnas.91.13.6040
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发表时间：
1994-06-21
影响因子：
11.1
通讯作者：
BURBACH, JPH
中科院分区：
文献类型：
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作者：
CHANG, CS;DASILVA, SL;BURBACH, JPH
我们已经确定了类固醇受体超家族的成员，并从人类和大鼠下丘脑，前列腺和睾丸cDNA文库中克隆。第一个ATG和终止子TGA之间的开放阅读框可编码615个（人）和596个（大鼠）氨基酸，计算分子量为67.3（人）和65.4（大鼠）kDa。这种蛋白质称为TR4孤儿受体，其氨基酸序列与先前鉴定的TR2孤儿受体密切相关。TR2和TR4孤儿受体之间的高度同源性表明这两种孤儿受体构成类固醇受体超家族中的独特亚家族。这两种孤儿受体在大鼠组织中差异表达。与TR2孤儿受体不同，TR4孤儿受体似乎主要位于海马和小脑的颗粒细胞中，这表明它可能在这些神经元中的转录调控中发挥某些作用。
We have identified a member of the steroid receptor superfamily and cloned it from human and rat hypothalamus, prostate, and testis cDNA libraries. The open reading frame between first ATG and terminator TGA can encode 615 (human) and 596 (rat) amino acids with calculated molecular mass of 67.3 (human) and 65.4 (rat) kDa. The amino acid sequence of this protein, called TR4 orphan receptor, is closely related to the previously identified TR2 orphan receptor, The high homology between TR2 and TR4 orphan receptors suggests that these two orphan receptors constitute a unique subfamily within the steroid receptor superfamily. These two orphan receptors are differentially expressed in rat tissues. Unlike TR2 orphan receptors, the TR4 orphan receptor appears to be predominantly located in granule cells of the hippocampus and the cerebellum, suggesting that it may play some role(s) in transcriptional regulation in these neurons.