Neural activity in human hippocampal formation reveals the spatial context of retrieved memories.
Neural activity in human hippocampal formation reveals the spatial context of retrieved memories.
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DOI：
10.1126/science.1244056
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发表时间：
2013-11-29
期刊：
影响因子：
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通讯作者：
Schulze-Bonhage A
中科院分区：
文献类型：
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作者：
Miller JF;Neufang M;Solway A;Brandt A;Trippel M;Mader I;Hefft S;Merkow M;Polyn SM;Jacobs J;Kahana MJ;Schulze-Bonhage A
在许多物种中，空间导航是由位置细胞网络支持的，每当动物处于环境的某个区域时，位置细胞网络就会表现出增强的放电。这种对位置的神经表征是否构成了情景记忆编码的时空背景的一部分？我们记录了癫痫患者执行混合空间记忆和情景记忆任务时内侧颞叶神经元的活动。我们确定了在虚拟导航中活跃的位置反应细胞，然后询问在随后的没有实际导航的导航相关记忆的回忆中是否同样的细胞被激活。在情景记忆提取过程中，位置反应细胞活动得以恢复。在提取每一段记忆的过程中，神经元的放电与表示记忆最初被编码的环境中位置的活动相似。
In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.