Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference
Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference
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DOI：
10.3390/cancers11081125
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发表时间：
2019-08-01
期刊：
影响因子：
5.2
通讯作者：
Prencipe, Maria
中科院分区：
文献类型：
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作者：
Charmsaz, Sara;Collins, Denis M.;Prencipe, Maria
虽然传统的癌症治疗，如手术，放疗和化疗，已经结合了几十年来努力治疗癌症患者，癌症研究的新领域的出现导致了对传统治疗与更创新方法相结合的新兴趣。认识到癌症进展不仅是由于癌上皮细胞的变化，而且还涉及肿瘤微环境的变化，为联合治疗开辟了新的途径。在这里，我们讨论了在第55届爱尔兰癌症研究协会（IACR）年会上提出的联合治疗的使用，突出了新的治疗策略的例子，与传统疗法相结合，不仅可以大大提高患者的整体疗效，而且可以提高癌症幸存者的生活质量。在新的治疗策略，免疫代谢，表观遗传疗法和体育锻炼。此外，还讨论了精准医学领域的新技术，这些技术将有助于发现新的治疗方法并对患者进行分层以进行联合治疗。
While conventional cancer treatments, such as surgery, radiotherapy and chemotherapy, have been combined for decades in an effort to treat cancer patients, the emergence of novel fields of cancer research have led to a renewed interest in combining conventional treatments with more innovative approaches. The realisation that cancer progression is not exclusively due to changes in the cancer epithelial cells, but also involves changes in the tumour microenvironment, has opened new avenues for combination treatments. Here we discuss the use of combination therapies presented at the 55th Irish Association for Cancer Research (IACR) Annual Conference, highlighting examples of novel therapeutic strategies which, combined with conventional therapies, may greatly enhance not only the overall outcome for patients, but also the quality of life for cancer survivors. Among the novel treatment strategies, immune metabolism, epigenetic therapies and physical exercise are presented. In addition, novel technologies in the field of precision medicine, which will be useful to discover new therapeutics and to stratify patients for combination treatments, are also discussed.