Cognitive function during early abstinence from opioid dependence: a comparison to age, gender, and verbal intelligence matched controls.
Cognitive function during early abstinence from opioid dependence: a comparison to age, gender, and verbal intelligence matched controls.
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阿片类药物依赖性早期戒酒期间的认知功能：与年龄，性别和言语智力相匹配的控制的比较。
DOI：
10.1186/1471-244x-6-9
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发表时间：
2006-02-24
期刊：
影响因子：
4.4
通讯作者：
Kalska H
中科院分区：
文献类型：
--
作者：
Rapeli P;Kivisaari R;Autti T;Kähkönen S;Puuskari V;Jokela O;Kalska H
阿片类药物依赖者在滥用期间在注意力、工作记忆、情景记忆和执行功能方面存在认知缺陷。长期禁欲后，一致的认知缺陷已被发现只在执行功能。然而，很少有研究探讨禁欲最初几周的认知功能。本研究的目的是研究阿片类药物依赖者在早期戒断过程中的认知功能。据推测，认知缺陷在戒断症状高峰过去后立即明显，然后部分恢复。15例阿片类药物依赖患者和15例年龄、性别和语言智力相匹配的对照者进行了认知测试。当患者表现比对照者差时，分析了认知表现与戒断天数、阿片类药物滥用持续时间、任何物质滥用持续时间或阿片类药物戒断症状量表评分（简短阿片类药物戒断量表）之间的相关性。早期戒断的阿片类药物依赖患者在测量复杂工作记忆、执行功能和液体智力的测试中的表现在统计学上显著差于对照组。他们的复杂工作记忆和流体智力表现与戒断天数有统计学显著相关性。结果表明，相当普遍的神经认知缺陷，在高阶认知。这表明，认知功能障碍在早期戒断阿片类药物依赖有关的戒断诱导的神经失调，在前额叶皮层和部分是短暂的。
Individuals with opioid dependence have cognitive deficits during abuse period in attention, working memory, episodic memory, and executive function. After protracted abstinence consistent cognitive deficit has been found only in executive function. However, few studies have explored cognitive function during first weeks of abstinence. The purpose of this study was to study cognitive function of individuals with opioid dependence during early abstinence. It was hypothesized that cognitive deficits are pronounced immediately after peak withdrawal symptoms have passed and then partially recover. Fifteen patients with opioid dependence and fifteen controls matched for, age, gender, and verbal intelligence were tested with a cognitive test battery When patients performed worse than controls correlations between cognitive performance and days of withdrawal, duration of opioid abuse, duration of any substance abuse, or opioid withdrawal symptom inventory score (Short Opiate Withdrawal Scale) were analyzed. Early abstinent opioid dependent patients performed statistically significantly worse than controls in tests measuring complex working memory, executive function, and fluid intelligence. Their complex working memory and fluid intelligence performances correlated statistically significantly with days of withdrawal. The results indicate a rather general neurocognitive deficit in higher order cognition. It is suggested that cognitive deficit during early abstinence from opioid dependence is related to withdrawal induced neural dysregulation in the prefrontal cortex and is partly transient.