To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
复制标题
死还是不死：调节反馈磷酸化电路决定受体相互作用蛋白激酶 1 (RIPK1) 功能
DOI：
10.1080/23723556.2017.1396389
复制
发表时间：
2017
影响因子：
2.1
通讯作者：
Gaestel M
中科院分区：
文献类型：
--
作者：
Menon MB;Gropengießer J;Ruckdeschel K;Gaestel M
复杂的翻译后修饰决定了受体相互作用蛋白激酶-1（RIPK 1）对细胞存活和死亡的影响。我们和其他人的研究揭示了RIPK 1信号转导中的p38 MAPK/MK2依赖性检查点。MAPKAP激酶2（MK 2）磷酸化RIPK 1，以抑制RIPK 1介导的细胞凋亡和坏死性凋亡，以响应与炎症，感染，遗传毒性应激和化疗相关的各种刺激。
Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.