Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery
Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery
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DOI：
10.1086/368205
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发表时间：
2003-02-01
影响因子：
6.4
通讯作者：
Witkin, SS
中科院分区：
文献类型：
--
作者：
Gerber, S;Vial, Y;Witkin, SS
解脲原体是最常从早产妇女羊水中分离出来的微生物。探讨健康孕中期孕妇羊膜内解脲菌与妊娠结局的关系。采用聚合酶链反应（PCR）对254例妊娠15-17周无症状妇女的经腹羊水进行检测。29例（11.4%）检出解脲菌。随后的早产发生在17例（58.6%）U.脲脲阳性妇女中，而10例（4.4%）U.脲脲阴性妇女中（P < 0.001）。7例（24.1%）u型脲脲酶阳性妇女早产，而u型脲脲酶阴性妇女早产仅1例（0.4%）（P < 0.0001）。脲脲酶阳性的妇女在先前妊娠中早产的发生率（20.7%）也高于阴性妇女（2.7%;P = 0.0008）。PCR检测妊娠中期羊水的解脲脲菌可以确定妇女在随后的早产和分娩的风险。
Ureaplasma urealyticum is the microorganism most frequently isolated from the amniotic fluid of women in preterm labor. The relationship between intra-amniotic U. urealyticum in healthy second-trimester pregnant women and subsequent pregnancy outcome was investigated. Transabdominal amnioticfluid obtained from 254 asymptomatic women at 15-17 weeks' gestation were tested by polymerase chain reaction (PCR). U. urealyticum was identified in 29 subjects (11.4%). A subsequent preterm labor occurred in 17 U. urealyticum-positive women (58.6%), compared with 10 (4.4%) U. urealyticum-negative women (P < .001). Preterm birth was documented in 7 (24.1%) U. urealyticum-positive women compared with only 1 U. urealyticum-negative woman (0.4%) (P < .0001). U. urealyticum-positive women also had a higher prevalence of preterm labor in a prior pregnancy (20.7%) than did the negative women (2.7%; P = .0008). PCR testing of second-trimester amniotic fluid for U. urealyticum can identify women at risk for subsequent preterm labor and delivery.