AFRICAN BURKITT'S LYMPHOMA AND AN EPSTEIN-BARR VIRUS-ENHANCING PLANT EUPHORBIA TRIUCALLI
AFRICAN BURKITT'S LYMPHOMA AND AN EPSTEIN-BARR VIRUS-ENHANCING PLANT EUPHORBIA TRIUCALLI
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非洲伯基特淋巴瘤和增强 Epstein-Barr 病毒的植物大戟
DOI：
10.1016/s0140-6736(87)92700-0
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Mugambi
中科院分区：
文献类型：
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作者：
T. Osato;S. Imai;S. Koizumi;F. Mizuno;T. Aya;T. Kinoshita;H. Tokuda;Y. Ito;N. Hirai;H. Ohigashi;M. Hirota;K. Koshimįzu;W. Kofi;J. Were;M. Mugambi
在1984-86年在肯尼亚和坦桑尼亚的调查中，作者注意到Burkitt淋巴瘤的地方性与大戟的大量繁殖相吻合。该植物的茎和叶的提取物在含有潜伏的EBV基因组的Raji细胞中显着地诱导EB病毒早期抗原。还可诱导病毒衣壳抗原合成。此外，它们还增强了EBV诱导的淋巴细胞转化。从这种植物生长的地方提取的土壤、蔬菜和水库饮用水也有类似的效果。活性主体被鉴定为4-脱氧佛波酯，其活性类似于一种有效的肿瘤促进剂。在维多利亚湖流域地区，这种植物每天都被用作草药，由于山羊吃了这种叶子，这种化合物可能会进入食物链。作者认为，当疟疾降低EB病毒特异性细胞免疫时，增强EB病毒的效果更加明显。Newline˜D.W.Fitzsimons
In surveys in Kenya and Tanzania in 1984-86 the authors noted that endemicity of Burkitt's lymphoma coincided with profusion ofEuphorbia tirucalli.Extracts of the stalks and leaves of the plant strikingly induced Epstein-Barr virus early antigen in Raji cells harbouring latent EBV genome. Viral capsid antigen synthesis was also induced. Further, they enhanced EBV-induced transformation of lymphocytes. Extracts of soil, vegetables and reservoir drinking water taken from sites where the plant grew had similar effects. The active principal was identified as a 4-deoxyphorbol ester with activity similar to a potent tumour promoter. The plant is used daily in the Lake Victoria Basin region as a herbal medicine and as the leaves are eaten by goats the compound may enter the food chain. The authors suggest that the EBV-enhancing effect is more clearly manifest when malaria lowers EBV-specific cellular immunity.newline˜D.W. FitzSimons