The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study.
The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study.
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DOI：
10.1038/s41533-018-0074-x
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发表时间：
2018-02-21
影响因子：
3.1
通讯作者：
Hasegawa K
中科院分区：
文献类型：
--
作者：
Goto T;Faridi MK;Camargo CA;Hasegawa K
Little is known about the effect of long-term aspirin use on acute severity of COPD. We hypothesized that, in patients hospitalized for acute exacerbation of COPD (AECOPD), long-term aspirin use is associated with lower risks of disease severity (in-hospital death, mechanical ventilation use, and hospital length-of-stay). We conducted a retrospective cohort study using large population-based data from 2012 through 2013. Among 206,686 patients (aged ≥40 years) hospitalized for AECOPD, aspirin users had lower in-hospital mortality (1.0 vs. 1.4%; OR 0.60 [95% CI 0.50–0.72]; P < 0.001) and lower risk of invasive mechanical ventilation use (1.7 vs. 2.6%; OR 0.64 [95% CI 0.55–0.73]; P < 0.001) compared to non-users, while there was no significant difference in risks of non-invasive positive pressure ventilation use. Length-of-stay was shorter in aspirin users compared to non-users (P < 0.001). In sum, in patients with AECOPD, aspirin use was associated with lower rates of in-hospital mortality and invasive mechanical ventilation use, and shorter length-of-stay.
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影响因子：
10
作者：
Harrison, Michelle T.;Short, Philip;Schembri, Stuart
通讯作者：
Schembri, Stuart
影响因子：
9.6
作者：
Ford ES
通讯作者：
Ford ES
DOI：
10.1186/s13054-015-1091-6
发表时间：
2015-10-23
期刊：
Critical care (London, England)
影响因子：
--
作者：
Toner P;McAuley DF;Shyamsundar M
通讯作者：
Shyamsundar M
影响因子：
8.8
作者：
Gando, Satoshi
通讯作者：
Gando, Satoshi
影响因子：
10
作者：
Maclay, John D.;McAllister, David A.;MacNee, William
通讯作者：
MacNee, William