Processing of food pictures: Influence of hunger, gender and calorie content
Processing of food pictures: Influence of hunger, gender and calorie content
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DOI：
10.1016/j.brainres.2010.04.030
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发表时间：
2010-09-02
期刊：
影响因子：
2.9
通讯作者：
Preissl, Hubert
中科院分区：
文献类型：
--
作者：
Frank, Sabine;Laharnar, Naima;Preissl, Hubert
在大多数情况下，肥胖是2型糖尿病和其他相关慢性疾病的主要危险因素，是由过度饮食引起的。为了更好地了解饮食行为，有必要确定它是如何被食物的卡路里含量，饱腹感和性别等因素所调节的。12名健康正常体重的参与者（6名女性）进行了功能性磁共振成像（fMRI）研究。为了防止社会可接受性的影响，刺激呈现采用内隐一回任务。我们提出了食物（高热量和低热量）和非食物的图片在一个块的设计和受试者必须指出按钮按下是否两个连续的图片是相同的或不。每个受试者在两个不同的日子里在饥饿和饱足的状态下执行任务。与低热量图片相比，高热量图片导致食物加工和奖励相关区域（如眶额和岛叶皮层）的活动增加。此外，我们发现视觉区域（枕叶）的激活差异，尽管事实上，刺激匹配他们的物理特征。详细的调查还显示性别特异性的影响，梭状回。女性在饥饿状态下观看高热量图片时，梭状回的激活程度更高。这项研究表明，食物图片的卡路里含量调节了与奖励处理相关的大脑区域甚至早期视觉区域的激活。此外，饱足感似乎对男性和女性处理食物图片的影响不同。即使使用了内隐任务，也可以在眶额皮层中观察到激活差异，已知眶额皮层在与食物相关的刺激的外显刺激期间被激活。(C)2010 Elsevier B.V.保留所有权利。
In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve healthy normal weighted participants (six female) were investigated in a functional magnetic resonance imaging (fMRI) study. In order to prevent the influence of social acceptability, an implicit one-back task was chosen for stimulus presentation. We presented food (high- and low-caloric) and non-food pictures in a block design and subjects had to indicate by button press whether two consecutive pictures were the same or not. Each subject performed the task in a hungry and satiated state on two different days. High-caloric pictures compared to low-caloric pictures led to increased activity in food processing and reward related areas, like the orbitofrontal and the insular cortex. In addition, we found activation differences in visual areas (occipital lobe), despite the fact that the stimuli were matched for their physical features. Detailed investigation also revealed gender specific effects in the fusiform gyrus. Women showed higher activation in the fusiform gyrus while viewing high-caloric pictures in the hungry state. This study shows that the calorie content of food pictures modulates the activation of brain areas related to reward processing and even early visual areas. In addition, satiation seems to influence the processing of food pictures differently in men and women. Even though an implicit task was used, activation differences could also be observed in the orbitofrontal cortex, known to be activated during explicit stimulation with food related stimuli. (C) 2010 Elsevier B.V. All rights reserved.