The beneficial influence of microarc oxidation-coated magnesium alloy on the adhesion, proliferation and osteogenic differentiation of bone marrow stromal cells
The beneficial influence of microarc oxidation-coated magnesium alloy on the adhesion, proliferation and osteogenic differentiation of bone marrow stromal cells
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DOI：
10.1016/j.matlet.2014.09.002
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发表时间：
2014-12
影响因子：
3
通讯作者：
Taozhou Zhang;Xiaona Wu;Hua-yang Huang;Yu Zhang;Mei Li;Guobo Lan;Hong Xia;Qing‐shui Yin
中科院分区：
文献类型：
--
作者：
Taozhou Zhang;Xiaona Wu;Hua-yang Huang;Yu Zhang;Mei Li;Guobo Lan;Hong Xia;Qing‐shui Yin
镁基材料的快速腐蚀速度阻碍了其临床应用。为提高镁合金AZ 31 B的耐腐蚀性能，在镁合金表面制备了微弧氧化膜层，并对其表面形貌和降解行为进行了研究。观察MAO-AZ 31 B对骨髓基质细胞（BMSCs）黏附、增殖及成骨分化的影响。与未涂层相比，MAO-AZ 31 B表现出超过五周的长期耐腐蚀性。细胞实验表明，与未涂层相比，微弧氧化涂层能促进骨髓基质细胞的粘附、增殖和诱导成骨分化。因此，微弧氧化显示出有益的效果的耐腐蚀性，从而提高细胞粘附到可生物降解的AZ 31 B，是一种有前途的生物医用镁合金的表面改性方法。
The rapid corrosion rate hinds the clinical application of magnesium-based materials. Therefore, microarc oxidation (MAO) coatings were fabricated on a magnesium alloy named AZ31B to improve its anti-corrosion ability, while the surface morphology and degradation behavior were studied. The adhesion, proliferation and osteogenic differentiation of bone marrow stromal cells (BMSCs) cultured with MAO–AZ31B were investigated. In contrast to uncoated one, MAO–AZ31B performed a long-term corrosion resistance for more than five weeks. Evidenced by cell test, MAO coatings could promote BMSCs adhesion, proliferation and induced osteogenic differentiation in comparison with uncoated samples. Thus MAO showed beneficial effects on the corrosion resistance of, and thus improved cell adhesion to the biodegradable AZ31B, and is a promising method for surface modification of biomedical magnesium alloys.