Stressed and Inflamed, Can GSK3 Be Blamed?
Stressed and Inflamed, Can GSK3 Be Blamed?
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DOI：
10.1016/j.tibs.2016.10.009
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发表时间：
2017-03
影响因子：
13.8
通讯作者：
Beurel E
中科院分区：
文献类型：
--
作者：
Jope RS;Cheng Y;Lowell JA;Worthen RJ;Sitbon YH;Beurel E
心理压力对我们的生活影响无处不在。在许多情况下，适应压力会增强机体的力量，但长期或严重的压力通常是有害的。心理压力的一个令人惊讶的结果是激活炎症反应，类似于感染或创伤引起的炎症。过度的心理压力和随之而来的大脑炎症会增加精神疾病的易感性，如抑郁症，并损害学习和记忆，包括一些有认知缺陷的患者。控制应激和炎症的有害结果的一个新兴靶点是糖原合成酶激酶-3(GSK3)。GSK3促进炎症，部分是通过调节炎症信号通路中的关键转录因子，而GSK3可以通过促进炎症和抑制长时程增强(LTP)来损害学习。事实证明，抑制GSK3的药物可能有助于控制过度应激引起的情绪和认知障碍以及相关的神经炎症。
Psychological stress has a pervasive influence on our lives. In many cases adapting to stress strengthens organisms, but chronic or severe stress is usually harmful. One surprising outcome of psychological stress is activation of an inflammatory response, resembling inflammation caused by infection or trauma. Excessive psychological stress and the consequential inflammation in the brain can increase susceptibility to psychiatric diseases, such as depression, and impair learning and memory, including in some patients with cognitive deficits. An emerging target to control detrimental outcomes of stress and inflammation is glycogen synthase kinase-3 (GSK3). GSK3 promotes inflammation, partly by regulating key transcription factors in the inflammation signaling pathway, and GSK3 can impair learning by promoting inflammation and by inhibiting long term potentiation (LTP). Drugs inhibiting GSK3 may prove beneficial for controlling mood and cognitive impairments caused by excessive stress and the associated neuroinflammation.